Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-aging Effect of Amino Acid Complex on the Skin

Amino Acid Complex의 항노화 작용

  • 김기호 ((주)바이오랜드 생명공학연구소) ;
  • 김기수 ((주)바이오랜드 생명공학연구소) ;
  • 김영희 ((주)바이오랜드 생명공학연구소) ;
  • 고강일 ((주)바이오랜드 생명공학연구소) ;
  • 박선희 ((주)바이오랜드 생명공학연구소) ;
  • 김진국 ((주)바이오랜드 생명공학연구소) ;
  • 최현진 ((주)바이오랜드 생명공학연구소) ;
  • 고수연 ((주)바이오랜드 생명공학연구소) ;
  • 배윤주 ((주)엘리드 피부과학연구소) ;
  • 김용민 ((주)바이오랜드 생명공학연구소)
  • Published : 2006.06.30
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Abstract

Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.

피부 각질층내의 아미노산 조성비율과 유사한 조성비로 amino acid complex을 제조하고, 제조된 amino acid complex가 피부에 미치는 영향을 알아보기 위해 세포 생존율, TIMP-1 발현 증가율, 보습 및 각질량 변화를 측정하였다. 연구 결과 amino acid complex는 독성이 없는 안전한 물질로 우수한 보습력 및 보습유지효과와 ascorbic acid와 유사한 TIMP-1 발현량 증가로 주름 예방 및 개선에 효과를 가지고 있으며, 각질량 감소 및 감소유지효과로 자극이 있는 AHA 대체 물질로의 가능성을 보였다. 따라서, amino acid complex는 다기능을 가진 노화방지 화장료 기능성분으로 유용하게 사용될 수 있음을 확인하였다.

Keywords

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