Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Effects of acute LeeKwaDoo administration on liver regeneration induced by partial hepatectomy in rats

부분 간절제술을 시행한 랫드에서 간재생에 관한 이과두주 급성투여에 따른 영향

  • Cho Jin-Youn (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Song Ji-Yae (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Ahn Jae-Bum (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Kim Hyun-Seok (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Kim Min-Su (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Im Hyun (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Lim Jun-Sung (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Shin Dong-Seok (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University) ;
  • Kim Hyun-Chul (Department of Veterinary Parasistology, College of Animal Resource Sciences, Kangwon National University) ;
  • Jung Ki-Soo (Department of Veterinary Parasistology, College of Animal Resource Sciences, Kangwon National University) ;
  • Shin Myung-Kyun (Gangwondo Veterinary Service Laboratory) ;
  • Lee Min-Jae (Department of Veterinary Lab Animal Medicine & Science, College of Animal Resource Science, Kangwon National University)
  • 조진연 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 송지예 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 안재범 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 김현석 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 김민수 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 임현 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 임준성 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 신동석 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실) ;
  • 김현철 (강원대학교 동물자원과학대학 수의학과 기생충학교실) ;
  • 정기수 (강원대학교 동물자원과학대학 수의학과 기생충학교실) ;
  • 신명균 (강원도가축위생시험소) ;
  • 이민재 (강원대학교 동물자원과학대학 수의학과 실험동물의학교실)
  • Published : 2006.03.01
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Abstract

Alcoholism and alcohol abuse are major public health concerns. This is linked to the injury of many organs, especially liver. Experiments were peformed to know the acute effects of LeeKwaDoo (LKD) induced by two-third partial hepatectomy (PH) in rats. In liver samples, regeneration parameters and histological assessment were performed. For the blood biochemical study, the blood were assayed with AST, ALT. The portal branch of liver lobes was ligated in the male Sprague-Dowley rats, two-thirds partial hepatectomies were also performed. It was estimated bodyweight and relative liver weight for the index of liver mass. For the marker of blood chemistry, we investigate the serum sample of rats and demonstrated the level of AST, ALT. Remaining tissues of liver developed as microscopic structures. Resection of the lobes in PH+LKD group resulted in a marked change of liver weight, blood chemistry and histological changes. The initiation of the proliferative response in PH group stimulated as well as reduction of the liver mass. On the other hands, the Initiation of the proliferative response in PH+LKD group delayed. Eventually, both PH group and PH+LKD group was restored relative liver weigh after 7 day. In conclusion, the acute adminstration of LKD seems to inhibit the initial response of liver regeneration through alcohol effects.

Keywords

References

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