The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Radix et Rhizoma Rhei on the Renal Function and Vessel in the Diabetic Rats

대황이 당뇨병 백서의 신장 및 혈관에 미치는 효과

  • Nam, Sang-Kyu (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Kim, Hyeong-Gu (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Kim, Hye-Yoon (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Lee, Jung-Sup (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Jung, Hyun-Ae (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Ko, Young-Chul (SamSe Oriental Hospital) ;
  • Shin, Sun-Ho (Department of Internal Medicine, College of Oriental Medicine, WonKwang University) ;
  • Jang, Tong-Young (Department of Internal Medicine, College of Oriental Medicine, WonKwang University)
  • 남상규 (원광대학교 한의과대학 심계내과학교실) ;
  • 김형구 (원광대학교 한의과대학 심계내과학교실) ;
  • 김혜윤 (원광대학교 한의과대학 심계내과학교실) ;
  • 이정섭 (원광대학교 한의과대학 심계내과학교실) ;
  • 정현애 (원광대학교 한의과대학 심계내과학교실) ;
  • 고영철 (삼세한방병원 내과학교실) ;
  • 신선호 (원광대학교 한의과대학 심계내과학교실) ;
  • 장통영 (원광대학교 한의과대학 심계내과학교실)
  • Published : 2006.12.31
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Abstract

Objectives : This study aimed at investigating whether aqueous extract of Radix et Rhizoma Rhei (AR) ameliorates renal and vascular complications in diabetic rats. Methods : The experiment operated for 6 weeks. The rats were divided into 4 groups: normal group, diabetic group (control group), diabetic group treated with AR (100 mg/kg/day) for the last 3 weeks, and diabetic group treated with AR (200 mg/kg/day) for the last 3 weeks. Results : There were no significant changes in the renal functional parameters by treatment of AR in the diabetic rats. Aorta segment in the diabetic rats revealed a thickening of intima and media, which was ameliorated by treatment with AR. The aortic expression level of endothelin-1 was also significantly attenuated by treatment with AR. Conclusions : Treatment with AR could not ameliorate renal functional defects, but improved vascular complication in diabetic rats.

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