Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Oxazolidinone Phosphonate Derivatives, Part II

  • Hwang, Jae-Min (Department of Environmental & Applied Chemistry, College of Engineering, Kangnung National University) ;
  • Yeom, Sung-Ho (Department of Environmental & Applied Chemistry, College of Engineering, Kangnung National University) ;
  • Jung, Kang-Yeoun (Department of Environmental & Applied Chemistry, College of Engineering, Kangnung National University)
  • Published : 2007.05.20
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Abstract

Several oxazolidinones, a new class of synthetic antibacterial agents, have shown biological activity against multidrug-resistant gram positive organisms such as staphylococci, streptococci, and enterococci. Previous results of our studies with benzoxazolidinone phosphonate derivatives have demonstrated very low antibacterial activity. In the course of our studies directed towards the discovery of noble antibacterial agents, we have synthesized several new derivatives of oxazolidinone phosphonates prepared efficiently from commercially available amino acids. These compounds are tested for in vitro antibacterial activity and one of the compounds showed promising results allowing us to pursue further studies.

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