Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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EXPERIMENTAL STUDY ON THE EFFECTS OF LOCAL IRRIGATION AND SYSTEMIC HEPARIN ADMINISTRATION ON MICROVASCULAR ANASTOMOSIS OF THE RABBIT FEMORAL ARTERY WITH INTENDED CRUSH INJURY

의도적 혈관 압박손상 후의 가토 대퇴동맥의 미세혈관 문합시 헤파린의 국소세척 및 전신투여 효과에 대한 실험적 연구

  • Kim, Dong-Joo (Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Moon, Seong-Yong (Department of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University) ;
  • Yoon, Jung-Hoon (Department of Oral Pathology, Oral Biology Research Institute, College of Dentistry, Chosun University)
  • 김동주 (조선대학교 치과대학 구강악안면외과학교실, 구강생물학연구소) ;
  • 김수관 (조선대학교 치과대학 구강악안면외과학교실, 구강생물학연구소) ;
  • 문성용 (조선대학교 치과대학 구강악안면외과학교실, 구강생물학연구소) ;
  • 윤정훈 (조선대학교 치과대학 구강병리학교실, 구강생물학연구소)
  • Published : 2007.03.31
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Abstract

This study compared the histological patency rates of anastomoses of the femoral artery. Twelve rabbits weighing about 2 kg were studied. Both the right and left femoral arteries were cut. The control group had no damage to the vessel, saline irrigation, and micro-anastomosis. Experimental group I had a crush injury to the vessel, saline irrigation, and micro-anastomosis. Experimental group II had a crush injury, saline irrigation, 100 U/ml heparin irrigation, and micro-anastomosis. Experimental group III had the same treatment as experimental group II plus the systemic application of 100 U/kg heparin iv. The histological patency rates were compared. The patency rates of the control group 30 min and 3 days after the anastomosis were 100 and 83%, respectively. The respective rates for experimental groups I and II 30 min and 3 days after the anastomosis were 100% in all cases. The respective rates in experimental group III were 100 and 83%. In this study, no significant correlation was observed between the patency rate and the effects of local irrigation or the systemic application of heparin on the microvascular anastomosis of the rabbit femoral artery. However, the patency rate tended to decrease concomitantly with an increase in surgery time. Increased bleeding was observed after the systemic application of heparin. Obvious damage to the crush-injured vascular endothelium was detected on histologic examination of the micro-anastomosed area. In addition, some vessels subjected to crush injury contained thrombi attached to the vascular endothelium. No preventive effect of heparin on thrombus formation was observed.

Keywords

References

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