The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Research on Effects of Cordyceps Sinensis in Spleen Cells of Mouse.

동충하초 추출물이 생쥐 비장세포에 미치는 영향

  • Lee, Jey-Young (Dept. of Herbology. College of Oriental Medicine, Daejeon University) ;
  • Roh, Seong-Soo (Dept. of Herbology. College of Oriental Medicine, Daejeon University) ;
  • Seo, Young-Bae (Dept. of Herbology. College of Oriental Medicine, Daejeon University)
  • 이제영 (대전대학교 한의과대학) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학)
  • Published : 2007.09.28
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Abstract

Objectives : This study was carried out to know the effect of Cordyceps sinensis(CS) on the immune inflammatory responses of spleen cells and function or immunocytes of the normal mouse. Methodes: We investigated effects of Cordyceps sinensis(CS) on normal immunocytes, gene expression of IL-12, IFN-$\gamma$ and surface-receptor expression of $CD3_{\epsilon}+$, CD4+, CD8+ and CD19+ cells were measured by PCR and FACS. Results : CS activated adhisive splenic cells morphologically as compared with the control group in the normal spleen cells of BALB/C mice. CS enhanced gene expression of interleukin-12 and interferon-gamma in a dose-dependent manner in the normal spleen cells of BALB/C mice. CS reduced the number of activating cells and surface-receptor expression of CD4+, CD8+ and CD19+. Conclusion : Cordyceps sinensis will be used as a stable remedium in the auto-immune diseases.

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