The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Research on Effects of Cordyceps Sinensis in Collagen Induced Arthritis Mouse-Model.

동충하초 추출물이 콜라겐으로 유발된 관절염 생쥐 모델에 미치는 영향

  • Shin, Mi-Kyung (Dept. of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Roh, Seong-Soo (Dept. of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Seo, Young-Bae (Dept. of Herbology, College of Oriental Medicine, Daejeon University)
  • 신미경 (대전대학교 한의과대학) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학)
  • Published : 2007.09.28
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Abstract

Objectives : We examined to know the effect of Cordyceps sinensis(CS) on arthritis mouse induced by type II collagen. Methods : To analyse immunomodulatory effects of CS, arthritis index, incidence, hind paw edema, DTH, spleen weight, the number of hemocytes, and surface-receptor expression of CD4+, CD8+ and CD19+ cells in DBA/IJ mice which is experimental model of arthritis induced by collagen were measured in vivo. Results: CS reduced arthritis index, incidence, hind paw edema and DTH significantly as compared with the control group in experimental model of arthritis induced by collagen. CS enhanced the spleen weight significantly as compared with the control group but didn't enhanced the number of leukocytes and thrombocytes in experimental model of arthritis. CS enhanced the number of activating cells and surface-receptor expression of CD4+, CD8+ cells as compared with the control group but didn't enhanced those of CD19+ cells in experimental model of arthritis. Conclusion : We found out that CS may have a suppressing effect againist auto-immune disease and will be need continuous research in looking for the more effective mechanism in the future.

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