The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Folium Perillae on cytokine productions in ischemic rats

소엽(蘇葉) 추출물이 뇌허혈이 유발된 백서의 cytokine분비에 미치는 영향

  • Yang, Gi-Ho (College of Oriental medicine, Dongshin University) ;
  • Kim, Hyung-Woo (College of Oriental medicine, Dongshin University) ;
  • Cho, Su-Jin (College of medicine, Korea University) ;
  • Kim, Sang-Dae (College of Oriental medicine, Dongshin University) ;
  • Yoon, Kwan-Hee (College of Oriental medicine, Dongshin University) ;
  • Kim, Bu-Yeo (College of Oriental medicine, Dongshin University) ;
  • Jeong, Hyun-Woo (College of Oriental medicine, Dongshin University) ;
  • Cho, Su-In (College of Oriental medicine, Dongshin University)
  • Published : 2007.09.28
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Abstract

Objective : The present study was carried out to investigate the effects of Folium Perillae (FP) on several cytokine production such as IL-1$\beta$, TNF-$\alpha$, IL-10 and TGF-$\beta$ to determine related mechanisma in Rats. Methods: So, we investigated the effects of FP on levels of several cytokines such as IL-l$\beta$, TNF-$\alpha$, IL-10 and TGF-$\beta$ in ischemic rats. Results: In this experiment, IL-10, an immune-modulatory cytckine, level was elevated by treatment with FP, but another regulatory cytokine, TGF-$\beta$1 level was not affected. On the other hand, levels of IL-l$\beta$ and TNF-$\alpha$, an inflammatory cytokines, were lowered by treatment with FP effectively. Conclusion : In conclusion, these results suggest that FP is useful to treat patient with disease related to cerebral ischemia, because FP can elevate IL-10 level, lower IL-l$\beta$ and TNF-$\alpha$ levels.

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