대한본초학회지 (The Korea Journal of Herbology)

  • 제22권3호
  • /
  • Pages.127-132
  • /
  • 2007
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

감국의 수지상세포의 성숙 억제 효과

Inhibitory effect of FLOS CHRYSANTHEMI on the maturation of dendritic cells

  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 최병민 (원광대학교 의과대학 생화학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental medicine, Wonkwang University) ;
  • Choi, Byung-Min (Dept. of Biochemistry, School of medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental medicine, Wonkwang University)
  • 발행 : 2007.09.28
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초록

Objectives : FLOS CHRYSANTHEMI (FC) has been reported to possess a variety of pharmacological activities. However, the effect of FC on the dendritic cells has not been determined. Methods : To examine the effect of FC on the immune response, we used several methods such as flow cytometric analyses, enzyme-linked immunosorbent assay. Results : 1. FC inhibited lipopolysacchride (LPS)-induced maturation of bone marrow-derived dendritic cells (BMDC) such as down-regulation of MHC class II and CD40. 2. FC also inhibited uptake of FITC-Dextran in BMDC stimulated with LPS. 3. Furthermore, FC inhibited several kinds of cytokine production such as TNF-a, IL-6 and IL-12 in BMDC. Conclusions : These results suggest that FC plays pivotal role m the development of inflammatory diseases.

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