Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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In vitro Activity of Kaempferol Isolated from the Impatiens balsamina alone and in Combination with Erythromycin or Clindamycin against Propionibacterium acnes

  • Lim, Young-Hee (Department of Clinical Laboratory Science College of Health Sciences, Korea University) ;
  • Kim, In-Hwan (Department of Food and Nutrition, College of Health Sciences, Korea Universuty) ;
  • Seo, Jung-Ju (Hazardous Substance Research Team, Korea Basic Science Institute)
  • Published : 2007.10.30
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Abstract

The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checkerboard test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were ${\leq}32\;{\mu}g/ml\;and\;{\leq}64{\mu}g/ml$ for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.

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References

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