Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Inhibitory Effects of Red Ginseng on Passive Cutaneous Anaphylaxis and Scratching Behavior Reactions in Mice

  • Published : 2007.09.30
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Abstract

To evaluate the antiatopic effect of Korea Red Ginseng (RG, steamed root of Panax ginseng C.A. Meyer, Family Araliaceae), its inhibitory effect on passive cutaneous anaphylaxis reaction and itching in mice was measured. RG and its ingredient saponin fraction (SF) potently inhibited passive cutaneous anaphylaxis (PCA) reaction and scratching behaviors. RG at a dose of 100 mg/kg and SF at a dose of 50 mg/kg significantly inhibited the scratching frequency by 32% and 38%, respectively. RG and SF also inhibited the degranulation and protein expression of tumor necrosis factor $(TNF)-{\alpha}$ and interleukin (IL)-4 of RBL-2H3 cells induced by IgE-antign complex. However, polysaccharide fraction of RG did not inhibit it. Based on these findings, RG can improve allergic skin disorders atopic dermatitis and contact dermatitis by the regulation of $TNF-{\alpha}$, and IL-4 produced by mast cells and basophils and their membrane stabilization.

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References

  1. Tanaka, N., Tanaka, O. and Shibata, S.: Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside $Rg_1,\;Rb_2$ and Rc. Chem. Pharm. Bull., 20, 1212-1216 (1972) https://doi.org/10.1248/cpb.20.1212
  2. Wu, J. Y., Gardner, B. H., Murphy, C. I., Seals, J. R., Kensil, C. R., Recchia, J., Beltz, G. A., Newman, G. W. and Newman, M. J.: Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J. Immunol., 148, 1519-1525 (1992)
  3. Kitagawa, I., Yoshikawa, M., Yoshihara, M., Hayashi, T. and Taniyama, T.: Chemical studies on crude drug precession. I. On the constituents of ginseng radix rubura (I). Yakugaku Zasshi 103, 612-622 (1983) https://doi.org/10.1248/yakushi1947.103.6_612
  4. Kown, S. W., Han, S. B., Park, I. H., Kim, J. M., Park, M. K. and Park, J. H.: Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J. Chromatogr. A, 921, 335-339 (2001) https://doi.org/10.1016/S0021-9673(01)00869-X
  5. Kim, W. Y., Kim, J. M., Han, S. B., Lee, S. K., Kim, N. D., Park, M. K., Kim, C. K. and Park, J. H.: Steaming of ginseng at high temperature enhances biological activity. J. Nat. Prod. 63, 1702-1704 (2000) https://doi.org/10.1021/np990152b
  6. Park, E. K., Choo, M. K., Han, M. J. and Kim, D. H.: Ginsenoside $Rh_1$ possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 133, 113-120 (2004) https://doi.org/10.1159/000076383
  7. Bae, E. A., Han, M. J., Choo, M. K., Park, S. Y. and Kim, D. H.: Metabolism of 20(S)- and 20(R)-ginsenoside $Rg_3$ by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull., 25, 58-63 (2002) https://doi.org/10.1248/bpb.25.58
  8. Kim, N. D., Kang, S. Y., Kim, M. J., Park, J. H. and Schini-Kerth, V. B.: The ginsenoside $Rg_3$ evokes endothelium-independent relaxation in rat aortic rings: role of $K^+$ channels. Eur J Pharmacol., 367, 51-57 (1999) https://doi.org/10.1016/S0014-2999(98)00899-1
  9. Nakata, H., Kikuchi, Y., Tode, T., Hirata, J., Kita, T., Ishii, K., Kudoh, K., Nagata, I. and Shinomiya, N.: Inhibitory effects of ginsenoside $Rh_2$ on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J. Cancer Res., 89, 733-740 (1998) https://doi.org/10.1111/j.1349-7006.1998.tb03278.x
  10. Tachikawa, E., Kudo, K., Harada, K., Kashimoto, T., Miyate, Y., Kakizaki, A. and Takahashi, E.: Effects of ginseng saponins on responses induced by various receptor stimuli. Eur. J. Pharmacol., 369, 23-32 (1999) https://doi.org/10.1016/S0014-2999(99)00043-6
  11. Bae, E. A., Han, M. J., Shin, Y. W. and Kim, D. H.: Antiallergic and antipsoriatic effects of Korean Red ginseng. J. Ginseng Res., 29, 80-85 (2005) https://doi.org/10.5142/JGR.2005.29.2.080
  12. Park, E. K., Choo, M. K., Han, M. J. and Kim, D.-H.: Ginsenoside $Rh_1$ possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol., 133, 113-120 (2004) https://doi.org/10.1159/000076383
  13. Choo, M. K., Park, E. K., Han, M. J. and Kim, D.-H.: Antiallergic activity of ginseng and its ginsenosides. Planta Med., 69, 518-522 (2003) https://doi.org/10.1055/s-2003-40653
  14. Park, E. K., Choo, M. K., Oh, J. K., Ryu, J. H. and Kim, D. H.: Ginsenoside $Rh_2$ reduces ischemic brain injury in rats. Biol. Pharm. Bull., 27, 433-436 (2004) https://doi.org/10.1248/bpb.27.433
  15. Yang, S. H., Seo, S. H., Kim, S. W., Choi, S. K. and Kim, D. H.: Effect of ginseng polysaccharide on the stability of lactic acid bacteria during freeze-drying process and storage. Arch. Pharm. Res., 29, 735-740 (2006) https://doi.org/10.1007/BF02974072
  16. Sugimoto, Y., Umakoshi, K., Nojiri, N. and Kamei, C.: Effect of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur. J. Pharmacol., 351, 1-5 (1998) https://doi.org/10.1016/S0014-2999(98)00288-X
  17. Shin, Y. W., Bae, E. A., Kim, S. S., Lee, Y. C. and Kim, D. H.: Effect of ginsenoside $Rb_1$ and compound K in chronic oxazolone-induced mouse dermatitis. Int. Immunopharmacol., 5, 1183-91 (2005) https://doi.org/10.1016/j.intimp.2005.02.016
  18. Bachert, C. and van Cauwenberge, P.: The WHO ARIA (allergic rhinitis and its impact on asthma) initiative. Chem. Immunol. Allergy, 82, 119-126 (2003) https://doi.org/10.1159/000071546
  19. Stevens, R. L. and Austen, K. F.: Recent advances in the cellular and molecular biology of mast cells. Immunology Today 10, 381-386 (1989) https://doi.org/10.1016/0167-5699(89)90272-7
  20. Lerner, E. A.: Chemical mediator of itching. In: Berhard J, editor. Itch: mechanisms and management of pruritis. New York: McGraw-Hill; 1944, p.23-25
  21. Hagermark, O.: Itch mediators. Semin Dermatol., 14, 271-276 (1955) https://doi.org/10.1016/S1085-5629(05)80047-1
  22. Schmeiz, M., Schmidt, R., Bickel, A., Handerker, H. O. and Torebjork, H. E.: Specific C-receptors for itch in human skin. J. Neurosci., 17, 8003-8008 (1997) https://doi.org/10.1523/JNEUROSCI.17-20-08003.1997
  23. Raid, D. S.: Pruritis of chronic cholestasis. Q. J. Med., 88, 603-607 (1955)