한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제25권6호
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  • Pages.452-457
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  • 2008
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Effects of Chitosan on Kidney Function in Streptozotocin-Induced Diabetic Mice

  • Sun, Kwang-Won (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Oh-Deog (College of Veterinary Medicine, Kyungpook National University)
  • 발행 : 2008.12.31
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초록

This study examined the effects of the daily administration of high-molecular-weight (HMW) chitosan in drinking water (0.8 %) on kidney function in streptozotocin (STZ)-induced diabetic ICR mice. The HMW chitosan lowered the blood urea nitrogen (BUN), serum and urine creatinine levels, urine protein levels, and albuminuria and reduced the kidney weight in STZ-induced type 1 diabetic ICR mice. On histopathological findings, capillary loops are open, but narrowed, and the mesangial matrix enlarged in the STZ-induced diabetic ICR mice. By contrast, the capillary loops and mesangial matrix of the chitosan-treated ICR mice were nearly normal compared with the STZ-induced diabetic ICR mice.

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참고문헌

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