Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Effect of Induction Chemotherapy Followed by Radiation Therapy of Locally Advanced Hypopharyngeal Carcinoma

국소진행된 하인두암에서 선행 항암화학요법과 방사선치료의 효과

  • Kim, Jae-Won (Department of Otolaryngology, College of Medicine, GyeongSang National University) ;
  • Son, Hee-Young (Department of Otolaryngology,, College of Medicine, GyeongSang National University) ;
  • Jeon, Sea-Yuong (Department of Otolaryngology, College of Medicine, GyeongSang National University) ;
  • Park, Jung-Je (Department of Otolaryngology, College of Medicine, GyeongSang National University) ;
  • Ahn, Seong-Ki (Department of Otolaryngology, College of Medicine, GyeongSang National University) ;
  • Kang, Ki-Mun (Department of Radiation Oncology, College of Medicine, GyeongSang National University) ;
  • Kim, Jin-Pyeong (Department of Otolaryngology, College of Medicine, GyeongSang National University)
  • 김재원 (경상대학교 의과대학 이비인후과학교실) ;
  • 손희영 (경상대학교 의과대학 이비인후과학교실) ;
  • 전시영 (경상대학교 의과대학 이비인후과학교실) ;
  • 박정제 (경상대학교 의과대학 이비인후과학교실) ;
  • 안성기 (경상대학교 의과대학 이비인후과학교실) ;
  • 강기문 (경상대학교 의과대학 방사선종양학과) ;
  • 김진평 (경상대학교 의과대학 이비인후과학교실)
  • Published : 2008.05.31
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Abstract

Purpose：Hypopharyngeal carcinoma is usually diagnosed as an advanced disease after an asymptomatic beginning, and it is related to a high frequency of lymph node metastases. An eventual negative outcome may occur not only because of possible locoregional failures but also for frequent distant metastases. Thus, the efficacy of induction chemotherapy followed by radiation therapy, with regards to the response, survival rate and complications for locally advanced hypopharyngeal carcinoma patients, was examined. Methods and Materials：Since July 1998 to February 2001, 18 patients having locally advanced hypopharyngeal carcinoma were treated with induction chemotherapy followed by radiation therapy, and the results were retrospectively analyzed. The regimen of the induction chemotherapy was the 5-flurouracil(5-FU, 1,000mg/$m^2$ daily for 5 consecutive days) and cisplatin(100mg/$m^2$ on day 1) combination at 3-week intervals for 2 cycles. The total radiation dose for the primary tumor and metastatic lymph nodes was 68.4-72.0Gy(median：70.2Gy) Results：The 3-year overall survival rate and disease free survival rate were 31.3% and 22.2%, respectively. In 6 patients(33.3%), preservation of the larynx for over 3 years was possible. After the induction chemotherapy and radiotherapy, a complete response was noted in 14 patients(77.8%), and a partial response in 4 patients (22.2%), with an overall response rate of 100%. Conclusion：Induction chemotherapy followed by radiation therapy is an effective treatment and larynx preservation rate was 33% in patients with locally advanced hypopharyngeal carcinoma in our report.

Keywords

References

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