한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제36권3호
  • /
  • Pages.240-245
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  • 2008
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

사염화탄소 유도 간독성에 대한 발효알로에의 보호효과

Protective Effects of Fermented Aloe vera on Carbon Tetrachloride-induced Hepatotoxicity in Sprague-dawley Rats

  • 임병락 ((주)에이치앤비티, 생명공학연구소)
  • 발행 : 2008.09.28
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초록

L. casei 균주를 이용하여 알로에를 발효한 결과 다당체의 분자량이 현저하게 저분자화 되었다. 사염화탄소로 유도된 흰쥐의 간과 혈청에서 간기능 활성, 항산화효소 활성 및 지질과산화에 미치는 발효알로에의 용량별 효과를 조사하였다. 14일 연속적으로 발효알로에(50, 100 mg/kg)을 경구투여 하였다. 알로에 투여군에서 SOD, CAT의 활성은 유의성있게 활성이 증가하였으며, AST, ALT, MDA 함량을 측정한 결과 용량 의존적으로 감소하였다. 이러한 결과로 미루어 볼때 발효알로에는 사염화탄소로 유발된 간독성에 대하여 항산화효소 활성을 증가시키며, 지질과산화를 억제하는 것으로 사료된다.

Aloe vera extract was fermented by Lactobacillus casei. The ability of fermented Aloe vera (FAV) as an antioxidant to protect against $CCl_4$-induced oxidative stress and hepatotoxicity in rats was investigated. The rats were administered orally with various doses of FAV with 50, 100 mg/kg for 14 consecutive days. For this study, we not only tested activity of various plasma enzymes (AST, ALT), which are used as indicators of liver disease, but also checked those change of liver components such as superoxide dismutase and catalase activity. Pretreatment of FAV for two weeks significantly reduced the elevated plasma enzyme activities induced by $CCl_4$. Pretreatment of FAV also restored the hepatic enzyme, malonedialdehyde (MDA) formation. The results indicate that FAV has a protective effect against acute hepatotoxicity induced by the administration of $CCl_4$ in rats, and that the hepatoprotective effects of FAV may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.

키워드

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