Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Loranthi Ramuluswatet Extract on Macrophages Activation and Th1 Response

상기생 물추출물이 대식세포 활성화와 Th1 반응에 미치는 효과

  • Shin, Hye-Young (Department of Infection Biology, Zoonosis Research Center, College of Medicine, Wonkwang University, Department of Oriental Medical Prescription, Cllege of Oriental Medicine, Wonkwang University) ;
  • Zhang, Wen-Ji (Department of Infection Biology, Zoonosis Research Center, College of Medicine, Wonkwang University, Department of Oriental Medical Prescription, Cllege of Oriental Medicine, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Yun, Yong-Gab (Department of Infection Biology, Zoonosis Research Center, College of Medicine, Wonkwang University, Department of Oriental Medical Prescription, Cllege of Oriental Medicine, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, Zoonosis Research Center, College of Medicine, Wonkwang University)
  • 신혜영 (원광대학교 인수공통감염병연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 장문희 (원광대학교 인수공통감염병연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 김윤철 (원광대학교 약학대학) ;
  • 윤용갑 (원광대학교 인수공통감염병연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 박현 (원광대학교 인수공통감염병연구센터 및 의과대학 감염생물학교실)
  • Published : 2008.02.25
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Abstract

In the recently, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the effect of the water extract of Loranthi Ramulus (LR) in production of inflammatory mediators and expression of toll-like receptor (TLR)-4, CD14 from peritoneal macrophage. We assayed the effect of LR water extract in cell proliferation in vitro and Th1/Th2 cytokine level in vivo. In peritoneal macrophages, water extract of LR water extract increased the production of Nitric oxide (NO) and $TNF-{\alpha}$. Also, LR water extract increased Con A-induced cell proliferation and IgG1, IgG2a level in serum. However, i.p. injection of water extract of LR water extract did not affect the level of $TNF-{\alpha}$, $IFN-{\gamma}$, IL-2, IL-4 and IL-5 in serum of mice. These studies indicate that LR water extract induces macrophage activation and suggest the possible use of LR water extract in macrophage-based immunotherapies.

Keywords

References

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