Extensive Rib Osteosarcoma with Intraperitoneal Invasion in a Small Breed Dog: Clinical and Histopathologic Findings

  • Lim, Chae-Young (Department of Veterinary Internal Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (BK21 program of Integrative network systems for veterinarians in basic science, industrial animals and preventive medicines, Konkuk University) ;
  • Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California) ;
  • Jung, Dong-In (Department of Veterinary Internal Medicine, Konkuk University) ;
  • Kim, Ju-Won (Department of Veterinary Internal Medicine, Konkuk University) ;
  • Kang, Byeong-Teck (Department of Veterinary Internal Medicine, Konkuk University) ;
  • Kim, Ha-Jung (Department of Veterinary Internal Medicine, Konkuk University) ;
  • Sur, Jung-Hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, Konkuk University)
  • Published : 2008.06.30

Abstract

An 11-year-old mixed breed male dog was presented with a thoracoabdominal wall mass of 3-year duration. Initial tentative diagnosis of osteosarcoma was made. Despite chemotherapy treatment, 72 days following the date of presentation, the dog was euthanized. Based upon necropsy and histopathologic findings, the tumor was definitely diagnosed as a combined type osteosarcoma of the rib. At necropsy examination, the tumor extended the left kidney and diaphragm, but distant metastasis was not found. The tumor's weight was 2.3kg and that was 38.3% of the dog's weight. This case report describes the clinicopathological, computed tomographic, histopathologic and immunohistochemical findings of extensive rib osteosarcoma in a small breed dog.

Keywords

References

  1. Bailey D, Erb H, Williams L, Ruslander D, Hauck M. Carboplatin and doxorubicin combination chemotherapy for the treatment of appendicular osteosarcoma in the dog. J Vet Intern Med 2003; 17: 199-205 https://doi.org/10.1111/j.1939-1676.2003.tb02434.x
  2. Baines SJ, Lewis S, White RA. Primary thoracic wall tumours of mesenchymal origin in dogs: a retrospective study of 46 cases. Vet Rec 2002; 150: 335-339 https://doi.org/10.1136/vr.150.11.335
  3. Berg J, Lamb CR, O'Callaghan MW. Bone scintigraphy in the initial evaluation of dogs with primary bone tumors. J Am Vet Med Assoc 1990; 196: 917-920
  4. Chun R, Garrett LD, Henry C, Wall M, Smith A, Azene NM. Toxicity and efficacy of cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma. J Am Anim Hosp Assoc 2005; 41: 382-387 https://doi.org/10.5326/0410382
  5. Cooley DM, Waters DJ. Skeletal neoplasms of small dogs: a retrospective study and literature review. J Am Anim Hosp Assoc 1997; 33: 11-23 https://doi.org/10.5326/15473317-33-1-11
  6. Davis GJ, Kapatkin AS, Craig LE, Heins GS, Wortman JA. Comparison of radiography, computed tomography, and magnetic resonance imaging for evaluation of appendicular osteosarcoma in dogs. J Am Vet Med Assoc 2002; 220: 1171-1176 https://doi.org/10.2460/javma.2002.220.1171
  7. Dernell WS, Straw RC, Withrow SJ. Tumors of the skeletal system. In: Small Animal Clinical Oncology, 3rd edn, Pennsylvania, W. B. Saunders. 2001: 378-417
  8. Feeney DA, Johnston GR, Grindem CB, Toombs JP, Caywood DD, Hanlon GF. Malignant neoplasia of canine ribs: Clinical, radiographic, and pathologic findings. J Am Vet Med Assoc 1982; 180: 927-933
  9. Goldie JH, Goldman AJ. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 1979; 63: 1727-1733
  10. Kent M, Strom SA, London CA, Seguin B. Alternating carboplatin and doxorubicin as adjunctive chemotherapy to amputation of limb-sparing surgery in the treatment of appendicular osteosarcoma in dogs. J Vet Intern Med 2004; 18: 540-544 https://doi.org/10.1111/j.1939-1676.2004.tb02582.x
  11. Kirpensteijn J, Kik M, Rutteman GR, Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol 2002; 39: 240-246 https://doi.org/10.1354/vp.39-2-240
  12. Leibman NF, Kuntz CA, Steyn PF, Fettman MJ, Powers BE, Withrow SJ, Dernell WS. Accuracy of Radiography, nuclear scintigraphy, and histopathlogy for determining the proximal extent of distal radius osteosarcoma in dogs. Vet Sur 2001; 30: 240-245 https://doi.org/10.1053/jvet.2001.23351
  13. Ling GV, Morgan JP, Pool RR. Primary bone tumors in the dog: A combined clinical, radiographic, and histologic approach to early diagnosis. J Am Vet Med Assoc 1974; 165: 55-67
  14. Matthiesen DT, Clark GN, Orsher RJ, Pardo AO, Glennon J, Patnaik AK. En bloc resection of primary rib tumors in 40 dogs. Vet Surg 1992; 21: 201-204
  15. Nakamura Y, Becker LE, Marks A. S-100 protein in tumors of cartilage and bone. An immunohistochemical study. Cancer 1983; 52: 1820-1824 https://doi.org/10.1002/1097-0142(19831115)52:10<1820::AID-CNCR2820521010>3.0.CO;2-3
  16. Pirkey-Ehrhart N, Withrow SJ, Straw RC, Ehrhart EJ, Page RL, Hottinger HL, Hahn KA, Morrison WB, Albrect MR, Hedlund CS, Hammer AS, HolmbergDL, Moore AS, King RR, Klausner JS. Primary rib tumors in 54 dogs. J Am Anim Hosp Assoc 1995; 31: 56-69
  17. Tompson KG, Pool RR. Tumors of bones. In: Tumors in domestic animals, 4th edn, Iowa, Iowa State Press 2002; 245-318
  18. Wallack ST, Wisner ER, Werner JA, Walsh PJ, Kent MS, Fairley RA, Hornof WJ. Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures. Vet Radiol Ultrasound 2002; 43: 432-441 https://doi.org/10.1111/j.1740-8261.2002.tb01030.x
  19. Zachos TA, Aiken SW, DiResta GR, Healey JH. Interstitial fluid pressure and blood flow in canine osteosarcoma and other tumors. Clin Orthop Rela Res 2001; 385: 230-236 https://doi.org/10.1097/00003086-200104000-00034