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Comparison study of Korean and Chinese ginsengs on the regulation of lymphocyte proliferation and cytokine production

한국 홍삼과 중국 홍삼의 경구 투여가 흰쥐의 림프구 증식과 Cytokine에 미치는 영향에 대한 비교 연구

  • Lee, Beom-Joon (Dep. of internal medicine, Kyunghee Korean Hospital) ;
  • Heo, Hong (Dep. of internal medicine, Kyunghee Korean Hospital) ;
  • Oh, Se-Choon (Dep. of internal medicine, Kyunghee Korean Hospital) ;
  • Lew, Jae-Hwan (The graduate school of East-West medical science, Kyunghee University)
  • 이범준 (경희의료원 강남경희한방병원 내상성인병센터) ;
  • 허홍 (경희의료원 강남경희한방병원 내상성인병센터) ;
  • 오세춘 (경희의료원 강남경희한방병원 내상성인병센터) ;
  • 류재환 (경희대학교 동서의학대학원 동서의학과)
  • Published : 2008.09.30

Abstract

Red ginseng is a medicinal herb widely used in East-Asia for a long time. Recently there have been a lot of studies about the effect of red ginseng on the immune responses. We investigated the differences between Korean red ginseng and Chinese red ginseng in the lymphocyte proliferation and cytokine production. The rats were divided into 3 groups, KRG(Korean Red Ginseng) group, CRG(Chinese Red Ginseng) group, and the Control group. Experimental groups were administered with Korean and Chinese red ginsengs for three months respectively. Then we obtained the lymphatic cells from spleen and compared the ability of KRG on the lymphocyte proliferation and the cytokine production after mitogen-stimulated culture to CRG. The proliferation of lymphocyte and level of $IL-1{\alpha}$ were significantly increased only in KRG group. There were significant increases in the level of $INF-{\gamma}$ in both KRG and CRG groups. There were no significant differences in the level of IL-2 and $TNF-{\alpha}$. These results indicate that KRG can induce infection-relevant immune responses much faster and higher than CRG. Furthermore, functional activation of CD8+ T-cell may be activated by red ginsengs.

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