The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Socheongryong-Tang on Immunoglobulin Production in Asthmatic Mice

소청용탕(小靑龍湯)이 천식(喘息)이 유발된 생쥐의 면역 글로불린 분비에 미치는 영향

  • Jung, Sun (College of Korean medicine, Dongshin University) ;
  • Cho, Su-Jin (College of medicine, Korea University) ;
  • Moon, Kyoung-Il (College of Korean medicine, Dongshin University) ;
  • Kim, Hyung-Woo (Research Center of Industrial Accelerators) ;
  • Kim, Bu-Yeo (School of Dentistry, Kyung Hee University) ;
  • Cho, Su-In (School of Oriental medicine, Pusan National University)
  • 정선 (동신대학교 한의과대학) ;
  • 조수진 (고려대학교 의과대학) ;
  • 문경일 (동신대학교 한의과대학) ;
  • 김형우 (산업용가속기이용 생물연구센터) ;
  • 김부여 (경희대학교 치의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Published : 2008.03.30
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Abstract

Objectives : Socheongryong-Tang(小靑龍湯, SCRT), a herbal remedy, has been widely used to treat respiratory disease such as cough and asthma in Oriental countries. Recent years SCRT was known as anti-allergic agent. However, its therapeutic mechanisms including immunoglobuline such as IgE, IgG1, IgG2a productions are unclear. Methods : We investigated the effects of SCRT on levels of antigen specific total antibody, IgE, IgG1, IgG2a using ELISA method in serum from allergen-induced asthma mice. Results : SCRT decreased level of antigen specific IgE significantly. And SCRT treated mice showed downward tendency of IgG1, a Th1 relative antibody, level. But, SCRT did not affect levels of antigen specific total antibody and IgG2a, a Th1 relative antibody. Conclusions : we demonstrated the strong possibility of SCRT as a complementary or alternative drug to western drug also demonstrated that regulation of Th1/Th2 imbalance may be one of mechanism contributed to treatment for respiratory disease by SCRT.

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