한국식생활문화학회지 (Journal of the Korean Society of Food Culture)

  • 제23권4호
  • /
  • Pages.521-528
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  • 2008
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  • 1225-7060(pISSN)
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  • 2288-7148(eISSN)
한국식생활문화학회 (Korean Society of Food Culture)
권호 표지
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구기자 분말 첨가 식이가 1% 고콜레스테롤 급여 흰쥐의 지질 대사에 미치는 영향

Effect of Lycii Fructus Powder on Lipid Metabolism in 1% Cholesterol Fed Rats

  • 한성희 (원광보건대학 식품영양과) ;
  • 박성혜 (원광디지털대학교 한방건강학과)
  • Han, Sung-Hee (Department of Food of Nutrition, Wonkwang Health Science College) ;
  • Park, Sung-Hyee (Department of Orinetal Health Care, Wonkwang Digital University)
  • 발행 : 2008.08.31
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초록

This study examined the effects of 2% Lycii fructus powder (LFP) supplementation on lipid metabolism in rats. Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. Then, 40 rats were divided into four diet groups: a normal diet group (NC), high cholesterol diet group (HC), normal diet plus 2% Lycii fructus powder (NC-LFP) group, and high cholesterol diet plus 2% Lycii fructus powder (HC-LFP) group. The HC group presented higher growth rates and liver weights than NC and NC-LFP however, growth rates and liver weights in the 2% LFP administered groups gradually decreased. HC also showed increased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels and decreased atherogenic index values, HDL-cholesterol, and phospholipid levels, whereas LFP group showed decreased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels as compared to HC. There were no differences in serum triglyceride, phospholipid, LDL-cholesterol, HDL-cholesterol, and free cholesterol concentrations between the normal diet groups (NC and NC-LFP). The high cholesterol diet groups (HC and HC-LFP) had significant increases in serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDHase) activities. And the 2% LFP administered groups had lower hepatic concentrations of total cholesterol and triglycerides than the HC groups. Overall, the results suggest that Lycii fructus powder has hypochloesterolemic effects by reducing serum and liver cholesterol contents.

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참고문헌

  1. Akiyoshi S, Takane F, Kunio K. 1982. Isolation of 1,2-dehydroalpha- cyperone and solavetivone from Lycium chinese. phytochemistry, 21:2986-2995 https://doi.org/10.1016/0031-9422(80)85085-0
  2. Allred JB. 1990. Elevated blood cholesterol, A risk for heart disease that decreased with advancd age. J Am Diet Assoc, 90:574-576
  3. Baker HJ, Lindsey JR, Weisbroth SH. 1984. The laboratory rat. Academic press Inc. New York. pp 123-139
  4. Bligh EG, Dyer JA. 1989. A rapid method of total lipid extraction and purfication. Can J Biochem Physiol, 37:911-917
  5. Cha JY, Cho YS, Yanagita T. 1999. Effects of cholesterol on heaptic phospholipid metabolism in rats fed a diet containing fish oil and beef tallow. J Food Sci Nutr, 4:125-129
  6. Choi SH, Lee MH, Shin CS, Sung C, Oh MJ, Kim CJ. 1996. Effects of storage condition on the quality of the wine and yakju made by Lycium chinense miller. Agriculture chemistry and biotechnology, 39:338-342
  7. Chung HK, Choi CS, Yang EJ, Kang MH. 2004. The effect of Lycii fructus beer intake on serum lipid profiles and antioxidant activity in rats. Korean J Food Cuture, 19(1):52-60
  8. Do JR, Kim SB, Park YH, Kim DS. 1993. Angiotensin-I converting enzyme inhibitory activity by component of traditional the material. Korean J Food Sci Technol, 25(3):456-460
  9. Frantz ID, Dawson EA, Ashman DL, Gatewood LC, Barth GE. 1989. Test of the effects of lipid lowering by diet on cardiovascular risk. The Minnesota coronary survey. Atherosclerosis, 9:129-135
  10. Gilliard SE, Nelson CR and Maxwell C. 1985. Assimilation of cholesterol by Lactobacillus acidophilus. Appl Environ Microbiol, 49:377-381
  11. Hagulund O, Loustarinen R, Wallin I. 1991. The effect of fish oil on triglyceride, cholsterol, fibrinogen and malodialdehyde in humans supplementes with vitamin. Eur J Nutr, 12:165-172
  12. Jang JY, Lee MK. 1998. Effects of serum lipid metabolism in rats with diet induced cholesterol mia. J Korean Soc Food Sci Nutr, 27:1211-1216
  13. Joo HK. 1988. Study on development of tea by utilizing Lycium chinense and cornus officinalis. Korean J Dietary culture, 3(3):377-387
  14. Kang JA and Kang JS. 1997. Effects of garlic and onion pn plasma an liver cholesterol and triglyceride and platelet aggregation in rate basal or cholesterol supplemented diets. Korean J Nutr, 32:132-138
  15. Kang YH, Park YH, Ha TY, Moon KD. 1996. Effects of pine needle extracts on serum and liver lipid contents in rats fed high fat diet. J Korean Soc Food Nutr, 25(3): 367-373
  16. Kang SM, Shim JY, Hwang SJ, Hong SG, Jang HE, Park MH. 2003. Effects of saengshik supplementation on health improvement in diet-induced hyperchole-sterolemic rats. J Korean Soc Food Sci Nutr, 32:906-912 https://doi.org/10.3746/jkfn.2003.32.6.906
  17. Ki HY, Song SW, Ha CS, Han SS. 1993. Effects of the population density on growth and various physiological values of Sprague-Dawely rats. Korean Jab Ani Sci, 9:71-82
  18. Kim NJ, Youn WG, Hong ND. 1994. Pharmacological effects of Lycium chinense. Kor J Pharmacogn, 25:264-271
  19. Kim HS, Park YS, Kim CI. 1998. Changes of serum lipid profiles after eating Lycii fructus in rats fed high fat diet. J Korean Soc Food Nutr, 31(3):263-270
  20. Kim BW, Roh KS. 2000. Study on the activity of GOT and GPT in the hepatotoxic rat treated Lycium chinense Mill. Korean J Biomed Lab Sci, 6:187-192
  21. Kim HP, Lee EJ, Kim YC, Kim J, Kim HK, Park JH, Kim SY, Kim YC. 2002. Zeaxanthine dipalmitate from Lycium chinenese fruit reduces experimentally induced hepatic fibrosis in rats. Biolgical & pharmaceutical bulletin, 25:390-392 https://doi.org/10.1248/bpb.25.390
  22. Korea national statistical office. 2008. The cause of death statistics 2006. Annual report on the cause of death statics. pp 20-30
  23. Levy RI. 1981. Cholesterol lipoprotein, apoproteins and heart disease; present status and future prospects. Clin Chem, 27:653-662
  24. Lee BY, Kim HM, Kim CJ, Park MH. 1992. Rheological properties of hot water extractable concentration of boxthorn(Lycii fructus) and mixed boxthorn. Korean J Food Sci Technol, 24(4):597-602
  25. Lee BC, Park JS, Kwak TS, Moon CS. 1998. Variation of chemical properties in collected boxthorn varieties. Korean J Breed, 30:267-272
  26. Lee KA, Chung HY. 2000. Inhibitory effects of extracts from parmelia austrosinensis and P. prasorediosa on postprandial hyperglycemia. Korea J Food & Nutr, 13:134-138
  27. Nam SM, Han SS, Oh DH, Jung ME, Kang IJ and Chung CK. 2002. Effects of eucommia ulmoides olivon ethanol extract on lipid metabolism and antioxidant enzymes activities of rats fed high fat. J Korean Soc Food Sci Nutr, 31(5):796-801 https://doi.org/10.3746/jkfn.2002.31.5.796
  28. Moon SJ. 1996. Nutrition problems of korean. Korean J Nutr, 29:371-380
  29. Oda T, Shikata T, Natio C, Suzuki H and Kanetaka T. 1970. Phospholipid fatty liver a report of three cases with a new type of fatty liver. Japn J Exp Med, 40:127-140
  30. Oh SL, Kim SS, Min BY, Chung DH. 1990. Composition of free sugars, free amino acids, non-volatile organic acids and tannins in the extracts of L chinensis, A acutilobak, S chinensis B and A sessilflorum S. Korean J Food Sci Technol, 22:76-81
  31. Park OJ. 1994. Plasma lipids and fecal extracton of lipids in rats fed a high fat diet, a high cholesterol diet or a low fat/high sucrose diet. Kor J Nutr, 27(8):785-794
  32. Park JS, Park JD, Lee BC, Choi KJ. 2000. Effects of extracts from various parts of Lycium chinense Mill. on proliferation of mouse spleen cells. Korean J Medical Crop Sci, 8(4):291-296
  33. Park EJ. 2002. Dietary carbohydrates effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentration. Br J Nutr, 87:247-253 https://doi.org/10.1079/BJN2001514
  34. Plaa GL, Charonneau M. 1994. Detection and evaluation of chemically induced liver injury. In principles and methods of toxicology. Hayes At Raven Press New York, 839-870
  35. Reeves PG, Nielsen FH, Fahey GC. 1993. AIN-93 Purified diets for laboratoary rodents final report of the American institute of nutrition and hoc writng committe on the reformulation of the AIN-76A rodent diet. J Nutr, 123:1939-1995 https://doi.org/10.1093/jn/123.11.1939
  36. Rosenfeld L. 1989. Lipoprotein analysis. Early methods in the diagnosis of atherosclerosis. Arch Pathol Lab Med, 113:1101-1110
  37. Sheo HJ, Jun SJ, Lee MY. 1986. Effects of Lycii fructus extract on experimentally induced damage and alloxan diabetes in rabbits. J Korean Soc Food Nutr, 15(3):136-143
  38. Shin JS, Kim KS, Jeong GH, Cheong CS. Cheong CS. 1997. Antidiabetic activity of Lycii fructs. Kor J Pharmacogn, 28:138-142
  39. Sohn IS, 1975. Studies on the hypercholesterolemia of koreans. Kor J Med, 18:354-357
  40. Sung IS, Kim MJ, Cho SY. 1997. Effect of quercus acutissima carruthers extracts on the lipid metabolism. J Kor Soc Food Sci Nutr, 26(2):327-333
  41. Yao T, Sato M, Kobay Y, Wasa T. 1985. A perometric assays of total and free cholesterol in serum by the combined use of immobilized cholesterol esterases and cholesterol oxidant reactors and peroxidase electrode in a flow injection system. Anal biochem 149:387-397 https://doi.org/10.1016/0003-2697(85)90587-1
  42. Youna WG, Kim NJ, Hong ND. 1994. Pharmacological effects of Lycium chinense. Kor J Pharmacon, 25:264-271
  43. You SY. 1988. Medicinal plant culture. Ohsung Press Co. Seoul. pp 244-253
  44. Yun YP, Kang WS, Lee MY. 1996. The antithrombotic effects of green tea catechins. J Food Hyg Safety, 11:77-82
  45. Yun JS, Chung BH, Kim NY, Seong NS, Lee HY, Kim JD. 2003. Screening of 94 plant species showing ACE inhibitory activity. Korean J Medicinal Crop Sci, 11:246-251
  46. Wooller LA, Spady DK and Dietschy JM. 1992. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. J Lipid Res, 33:77-88