Toxicological Research

  • 제24권3호
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  • Pages.183-188
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  • 2008
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Strain-dependent Differences of Locomotor Activity and Hippocampus-dependent Learning and Memory in Mice

  • Kim, Joong-Sun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University) ;
  • Yang, Mi-Young (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University) ;
  • Son, Yeong-Hoon (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University) ;
  • Kim, Sung-Ho (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University) ;
  • Kim, Jong-Choon (Department of Veterinary Toxicology, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University) ;
  • Kim, Seung-Joon (Department of Veterinary Obstetrics, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Yong-Duk (Department of Veterinary Anatomy, College of Veterinary Medicine, Cheju National University) ;
  • Shin, Tae-Kyun (Department of Veterinary Anatomy, College of Veterinary Medicine, Cheju National University) ;
  • Moon, Chang-Jong (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
  • 발행 : 2008.09.01
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초록

The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.

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참고문헌

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