Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Discoid lupus erythematosus (DLE) in a juvenile Alaskan Malamute dog

  • Kim, Ha-Jung (College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (College of Veterinary Medicine, Konkuk University) ;
  • Kim, Ju-Won (College of Veterinary Medicine, Konkuk University) ;
  • Park, Chul (School of Veterinary Medicine, University of California) ;
  • Lim, Chae-Young (College of Veterinary Medicine, Konkuk University) ;
  • Lee, Jong-Hwan (College of Veterinary Medicine, Konkuk University) ;
  • Quan, Fu-Shi (College of Medicine, The Catholic University of Korea) ;
  • Park, Hee-Myung (College of Veterinary Medicine, Konkuk University)
  • Accepted : 2009.03.19
  • Published : 2009.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Discoid lupus erythematosus (DLE) is an immune-mediated skin disease which requires histopathology and immunohistopathology in both dogs and humans. A 10-month-old, intact female Alaskan Malamute presented for depigmentation, swelling, alopecia, erythema, and crusting on the bridge of the nose and the nasal planum. Cytological examination of nasal lesions revealed numerous cocci and neutrophils. Histopathological features included of infiltration of mononuclear cells at the dermoepidermal junction. Direct immunofluorescence tests and immunohistochemistry exhibited positive IgG, IgM, IgA, CD3, CD18, and CD79a on the epidermal basement membranes and around adnexal glands. This case indicates both T cells and B cells are related to mechanism of canine DLE. This case report describes advanced diagnostic tests and clinical outcome with immune suppressive therapy in a rare juvenile canine DLE case.

Keywords

References

  1. Bryden SL, White SD, Dunston SM, Burrows AK,Olivry T. Clinical, histopathological and immunologicalcharacteristics of exfoliative cutaneous lupus erythematosusin 25 German short-haired pointers. VetDermatol 2005, 16, 239-252 https://doi.org/10.1111/j.1365-3164.2005.00468.x
  2. Chabanne L, Fournel C, Caux C, Bernaud J,Bonnefond C, Monier JC, Rigal D. Abnormalities oflymphocyte subsets in canine systemic lupus erythematosus.Autoimmunity 1995, 22, 1-8 https://doi.org/10.3109/08916939508995293
  3. Fournel C, Chabanne L, Caux C, Faure JR, RD, Magnol JP, Monier JC. Canine Systemic LupusErythematosus. I: A Study of 75 Cases. Lupus 1992,1, 133-139 https://doi.org/10.1177/096120339200100303
  4. Gerhauser I, Strothmann-Luerssen A, Baumgartner W. A case of interface perianal dermatitis in a dog: is this an unusual manifestation of lupus erythematosus? Vet Pathol 2006, 43, 761-764 https://doi.org/10.1354/vp.43-5-761
  5. Griffies JD, Mendelsohn CL, Rosenkrantz WS, Muse R, Boord MJ, Griffin CE. Topical 0.1%tacrolimus for the treatment of discoid lupuserythematosus and pemphigus erythematosus in dogs.J Am Anim Hosp Assoc 2004, 40, 29-41 https://doi.org/10.1046/j.1365-3164.2002.00298_3.x
  6. Griffin CE. Diagnosis and management of primary autoimmune skin diseases: a review. Semin Vet MedSurg (Small Anim) 1987, 2, 173-185
  7. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. SkinDiseases of the Dog and Cat: Clinical andHistopathologic Diagnosis. 2nd ed. pp. 52-55, Blackwell Publishing, Ames, 2005
  8. Perez J, Arce C, Moreno A, Mozos E, Rodriguez F,Llanes D. Comparison of three monoclonal and threepolyclonal antibodies in the immunohistochemicaldiagnosis of canine autoimmune skin diseases. VetDermatol 2002, 13, 231-236 https://doi.org/10.1046/j.1365-3164.2002.00306.x
  9. Scott DM, Miller WH, Griffin CE. Muller & Kirk's Small Animal Dermatology. 6th ed. pp. 667-779, Saunders, Philadelphia, 2001
  10. Scott DW, Miller WH Jr. Squamous cell carcinomaarising in chronic discoid lupus erythematosus nasallesions in two German shepherd dogs. Vet Dermatol1995, 6, 99-104 https://doi.org/10.1111/j.1365-3164.1995.tb00050.x
  11. Werner LL, Brown KA, Halliwell RE. Diagnosis ofautoimmune skin disease in the dog: correlation betweenhistopathologic, direct immunofluorescent and clinicalfindings. Vet Immunol Immunopathol 1983, 5, 47-64 https://doi.org/10.1016/0165-2427(83)90031-4