Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Nasal adenocarcinoma in a dog

개의 비강샘암종 증례

  • Yoon, Jeong-Sik (College of Veterinary Medicine, Jeju National University) ;
  • Jung, Ji-Youl (College of Veterinary Medicine, Jeju National University) ;
  • Jo, Suk-Hee (College of Veterinary Medicine, Jeju National University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine, Jeju National University) ;
  • Woo, Gye-Hyeong (Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Jeon, Jae-Nam (Kangnam Animal Hospital) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine, Jeju National University)
  • Accepted : 2009.03.12
  • Published : 2009.03.30
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Abstract

A 10-year old female Yorkshire terrier with nasal discharge and swelling was referred to the local animal hospital. Abnormal mass of right nasal cavity was detected in physical examination and radiography. According to the radiographs of the head, there was an evidence of bony destruction in right nose. Oronasal fistula was detected in right maxillary canine teeth. After surgical excision, the sample of nasal mass was refereed to Pathology Department of Veterinary Medicine in Jeju National University. Grossly, the enlarged mass was soft and 3 ${\times}$ 3 cm in size. Histopathologically, the neoplastic mass was composed of tubular to tubulopapillary structures which were lined by single to 6~7 layers of cuboidal to ciliated columnar cells. These neoplastic cells showed invasive tendency to adjacent normal parenchyma. They had uniform, round to oval nuclei, cytoplasm with small vacuoles and indistinct cellular margin. The number of mitotic figures was varied in different areas, ranged from 0 to 4 per high power field. Necrotic foci and infiltration of inflammatory cells including neutrophils, lymphocytes, and plasma cells also presented in the mass. Immunohistochemically, the neoplastic cells demonstrated strong positive reaction for cytokeratin (CK) 18 but were negative for CK 7 and 8. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as nasal adenocarcinoma originated from respiratory epithelium.

Keywords

References

  1. 권영삼, 장광호, 장인호. 개에서 비강내 종양 27 증례. 한국임상수의학회지 2002, 19, 383-386
  2. 정주현, 장진화, 오선경, 김경민, 이성옥, 이정민, 김학상, 윤정희, 최민철. 개에서 비강 샘암종의 영상 진단 증례. 한국임상수의학회지 2006, 23, 355-360
  3. 홍성혁, 김명철. CT 진단 후 비절개술 및 방사선요법으로 치료한 개의 비강 선암의 발생례. 한국임상수의학회지 2002, 19, 256-259
  4. Abecasis J, Viana G, Pissarra C, Pereira T, FonsecaI, Soares J. Adenocarcinomas of the nasal cavity andparanasal sinuses: a clinicopathological and immunohistochemicalstudy of 14 cases. Histopathology 2004, 45,254-259 https://doi.org/10.1111/j.1365-2559.2004.01949.x
  5. Beck ER, Withrow SJ. Tumors of the canine nasalcavity. Vet Clin North Am Small Anim Pract 1985, 15,521-533 https://doi.org/10.1016/S0195-5616(85)50055-8
  6. Blot WJ, Chow WH, McLaughlin JK. Wood dustand nasal cancer risk. A review of the evidence from North America. J Occup Environ Med 1997, 39, 148-156 https://doi.org/10.1097/00043764-199702000-00012
  7. Bradley PA, Harvey CE. Intra-nasal tumours in thedog: an evaluation of prognosis. J Small Anim Pract 1973, 14, 459-467 https://doi.org/10.1111/j.1748-5827.1973.tb06485.x
  8. Brouillard F, Fritsch J, Edelman A, Ollero M.Contribution of proteomics to the study of the role ofcytokeratins in disease and physiopathology. Proteomics Clin Appl 2008, 2, 264-285 https://doi.org/10.1002/prca.200780018
  9. Bukowski JA, Wartenberg D, Goldschmidt M. Environmental causes for sinonasal cancers in pet dogs,and their usefulness as sentinels of indoor cancer risk. J Toxicol Environ Health A 1998, 54, 579-591 https://doi.org/10.1080/009841098158719
  10. Clercx C, Wallon J, Gilbert S, Snaps F, CoignoulF. Imprint and brush cytology in the diagnosis of canineintranasal tumours. J Small Anim Pract 1996, 37, 423-427 https://doi.org/10.1111/j.1748-5827.1996.tb02441.x
  11. Fukui D, Bando G, Ishikawa Y, Kadota K.Adenosquamous carcinoma with cilium formation,mucin production and keratinization in the nasal cavityof a red fox (Vulpes vulpes schrencki). J Comp Pathol 2007, 137, 142-145 https://doi.org/10.1016/j.jcpa.2007.05.004
  12. MacEwen EG, Withrow SJ, Patnaik AK. Nasaltumors in the dog: retrospective evaluation of diagnosis,prognosis, and treatment. J Am Vet Med Assoc 1977,170, 45-48
  13. Madewell BR, Priester WA, Gillette EL, Snyder SP. Neoplasms of the nasal passages and paranasal sinusesin domesticated animals as reported by 13 veterinarycolleges. Am J Vet Res 1976, 37, 851-856
  14. Nemec A, Pavlica Z, Juntes P, Crossley DA. Advanced periodontal disease in a Yorkshire Terrierwith concurrent nasal cavity malignancy. Slov Vet Res2007, 44, 103-108
  15. Ninomiya F, Suzuki S, Tanaka H, Hayashi S, OzakiK, Narama I. Nasal and paranasal adenocarcinomaswith neuroendocrine differentiation in dogs. Vet Pathol2008, 45, 181-187 https://doi.org/10.1354/vp.45-2-181
  16. Reif JS, Cohen D. The environmental distribution ofcanine respiratory tract neoplasms. Arch EnvironHealth 1971, 22, 136-140 https://doi.org/10.1080/00039896.1971.10665823
  17. Solorzano IB, Mayagoitia AL, Trigo Tavera FJ.Clinico-pathological study of six dogs with nasalcarcinoma and adenocarcinoma: diagnosis and treatment.Vet Mex 2003, 34, 81-95
  18. Walter J. A cytokeratin profile of canine epithelial skintumours. J Comp Pathol 2000, 122, 278-287 https://doi.org/10.1053/jcpa.1999.0372
  19. Wilson DW, Dungworth DL. Tumors of therespiratory tract. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 365-373, Iowa StatePress, Ames, 2002