Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Hyperinsulinism in a dog with beta-cell neoplasia (insulinoma)

  • Yu, Do-Hyeon (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Jong-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Song, Ru-Hui (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Noh, Dong-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Li, Ying-Hua (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Mi-Jin (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Cho, Ara (Department of Veterinary Pathology, College of Veterinary Medicine,Chonbuk National University) ;
  • Kim, Bumseok (Department of Veterinary Pathology, College of Veterinary Medicine,Chonbuk National University) ;
  • Park, Jinho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonbuk National University)
  • Accepted : 2009.10.22
  • Published : 2009.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

A six-year-old female cocker spaniel presented with recurring episodes of pelvic limb weakness and intermittent seizures. Laboratory analysis revealed marked hypoglycemia and an elevated serum insulin concentration. A pancreatic beta-cell tumor at stage III ($T_1N_1M_1$) was diagnosed based on serial blood glucose and insulin measurements along with diagnostic imaging. The patient survived for 140 days after diagnosis with medical management, including frequent feeding and prednisolone therapy. On necropsy, necrosis and masses in the peripancreatic omentum and liver were found; pancreatic beta-cell neoplasia with metastasis to the liver was confirmed by histopathologic examination. This case reports hyper-insulinism in a dog presenting with hypoglycemic seizures.

Keywords

References

  1. Best JD, Chisholm DJ, Alford FP. Insulinoma: poor recognition of clinical features is the major problem in diagnosis. Med J Aust 1978, 2, 1-5
  2. Breitschwerdt EB, Loar AS, Hribernik TN, McGrath RK. Hypoglycemia in four dogs with sepsis. J Am Vet Med Assoc 1981, 178, 1072-1076
  3. Capen CC. Tumours of the endocrine glands. In:Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 684-688, Iowa State Press, Ames, 2002
  4. Edwards DF. It's time to unamend the insulin-glucose ratio. J Am Vet Med Assoc 1986, 188, 951-953
  5. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. 3rd ed. pp. 616-644, Saunders, St. Louis, 2004
  6. Fernandez NJ, Barton J, Spotswood T. Hypoglycemia in a dog. Can Vet J 2009, 50, 423-426
  7. Floyd JC Jr, Fajans SS, Pek S, Chance RE. A newly recognized pancreatic polypeptide; plasma levels in health and disease. Recent Prog Horm Res 1976, 33, 519-570
  8. Hess RS. Insulin-secreting islet cell neoplasia. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 6th ed. pp. 1560-1563, Elsevier Saunders, St. Louis, 2005
  9. Kruth SA, Feldman EC, Kennedy PC. Insulinsecreting nislet cell tumors: establishing a diagnosis and the clinical course for 25 dogs. J Am Vet Med Assoc 1982, 181, 54-58
  10. Lurye JC, Behrend EN. Endocrine tumors. Vet Clin North Am Small Anim Pract 2001, 31, 1083-1110 https://doi.org/10.1016/S0195-5616(01)50014-5
  11. Meleo K. Management of insuloma patients with refractory hypoglycemia. Probl Vet Med 1990, 2, 602-609
  12. Polton GA, White RN, Brearley MJ, Eastwood JM. Improved survival in a retrospective cohort of 28 dogs with insulinoma. J Small Anim Pract 2007, 48, 151-156 https://doi.org/10.1111/j.1748-5827.2006.00187.x
  13. Siliart B, Stambouli F. Laboratory diagnosis of insulinoma in the dog: a retrospective study and a new diagnostic procedure. J Small Anim Pract 1996, 37, 367-370 https://doi.org/10.1111/j.1748-5827.1996.tb02416.x
  14. Simpson KW, Stepien RL, Elwood CM, Boswood A, Vaillant CR. Evaluation of the long-acting somatostatin analogue octreotide in the management of insulinoma in three dogs. J Small Anim Pract 1995, 36, 161-165 https://doi.org/10.1111/j.1748-5827.1995.tb02870.x
  15. Steiner JM, Bruyette DS. Canine insulinoma. Compend Contin Educ Pract Vet 1996, 18, 13-23
  16. Thompson JC, Jones BR, Hickson PC. The amended insulin to glucose ratio and diagnosis of insulinoma in dogs. N Z Vet J 1995, 43, 240-243 https://doi.org/10.1080/00480169.1995.35900