Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Anti-proliferation Effect of Damina 909 on Pancreatic Cancer Cells in Tumor-Xenografted Nude Mice Model

  • Kim, Yu-Ri (Department of Biochemistry & Molecular Biology, Korea University) ;
  • Lee, Seung-Min (Department of Biochemistry & Molecular Biology, Korea University) ;
  • Seo, Sang-Hui (Department of Biochemistry & Molecular Biology, Korea University) ;
  • Lee, Seung-Ho (Department of Biochemistry & Molecular Biology, Korea University) ;
  • Kim, In-Kyoung (Department of Biochemistry & Molecular Biology, Korea University) ;
  • Jun, Hwang-Jeok (Department of Legal Medicine, College of Medicine, Korea University) ;
  • Nam, Jong-Hyun (GLAMI Co., LTD) ;
  • Kim, Meyoung-Kon (Department of Biochemistry & Molecular Biology, Korea University)
  • Published : 2009.03.31
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Abstract

In this study, we investigated the anti-proliferative effect of Damina 909 in human cancer cell lines and tumor-xenografted nude mice to elucidate its potential in treating many cancers. Damina 909 treatment resulted in inhibition of cell proliferation of human pancreatic cancer cells. Our in vivo study showed that the weight of pancreatic tumors in Damina 909-treated group were the lighter than control group. Consequently, the intake of food and water in Damina 909-treated group did not change, while those in control group were steadily decreased over a period of treatment. Moreover, Damina 909 treatment elevated the protein expression of p53 and p21 in pancreatic tumor of xenografted nude mice. In summary, compare to other human cancer cells such as prostate and hepatocyte, Damina 909 is most effectively inhibited proliferation of pancreatic cancer cells by increasing the expression of tumor suppressor genes. This led us to speculate that a candidate substance for effective cancer therapy of pancreatic cancer might be contained in Damina 909.

Keywords

References

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