The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Nephroprotective Effects of Taeksa-san Aqueous Extracts on Cisplatin-induced Rat Acute Renal Failure

택사산(澤瀉散) 추출물(抽出物)이 Cisplatin으로 유발(誘發)된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향(影響)

  • Yu, Dong-Jo (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Haany University) ;
  • Yoon, Kyeong-Min (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Haany University) ;
  • Jang, Su-Yeong (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Haany University) ;
  • Lee, Yeon-Keong (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Haany University) ;
  • Kang, Seok-Bong (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Haany University)
  • 유동조 (대구한의대학교 한의과대학 신계내과학교실) ;
  • 윤경민 (대구한의대학교 한의과대학 신계내과학교실) ;
  • 장수영 (대구한의대학교 한의과대학 신계내과학교실) ;
  • 이연경 (대구한의대학교 한의과대학 신계내과학교실) ;
  • 강석봉 (대구한의대학교 한의과대학 신계내과학교실)
  • Published : 2009.12.30
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Abstract

Objectives : This study was to observe the nephroprotective effects of the traditional prescription, Taeksa-san(TSS). TSS has generally been used for treating various renal diseases, including renal failure. Methods : Three different dosages of TSS extract were orally administered once a day for 28 days, At the 23rd day after TSS extract treatment, cisplatin was also treated. Then, 5 days after cisplatin treatment, all the rats (6 groups of 8 rats each) were sacrificed. Changes in the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg, of which the effects on cisplatin-induced acute renal failures are already confirmed. Results : Dramatic decrease of body weight, increase of kidney weight, increase of serum BUN and creatinine levels were detected in the cisplatin control as compared with the intact control. In addition, marked increase of kidney MDA contents and decrease of kidney GSH contents were also detected in the cisplatin control as compared with the intact control. This means that cisplatin-induced ARF is induced by oxidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment with all three different dosages of TSS extracts. Conclusion : This study suggests that TSS extracts show favorable effects on cisplatin-induced rat ARF.

Keywords

References

  1. E. Braunwald, A. Fauci, D.Kasper, S.Hauser, D. Longo and J. Jameson. Harrion's principles of internal medicine. 서울: 도서출판 MIP; 2006, p. 1794-803.
  2. 이천. 國譯 篇註 醫學入門 IV 雜病門. 서울: 남산당; 1991, p. 700.
  3. Lippman AJ, Helson C, Helson L, Krakoff IH. Clinical trials of cis-diamminedichloroplatinum (NSC-119875). Cancer Chemother Rep. 1973;57:191-200.
  4. Kavutcu M, Canbolat O, Ozturk S, Olcay E. Ulutepe S, Ekinci C, Gokhun IH, Durak I. Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin-treated guinea pigs: effects of vitamins E and C. Nephron. 1996;72:269-74. https://doi.org/10.1159/000188853
  5. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 1951:193:265-75.
  6. Dahle LK, Hill EG, Holman RT. The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters. Arch Biochem Biophys. 1951;193:265-75.
  7. Eyer P, Podhradsky D. Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent. Anal Biochem. 1986:153:57-66. https://doi.org/10.1016/0003-2697(86)90061-8
  8. Anderson RJ. Prevention and management of acute renal failure. Hosp Prac. 1993:28:61-75.
  9. 김동현, 김형민, 류종훈, 엄재영, 김상찬, 양재하, 조민경, 임종필, 홍승헌. 한방약리학. 서울: 신일상사; 2006, p. 49-53, 490-1, 496-8, 503-8, 532-4, 569-73, 610-3.
  10. Safirstein R, Winston J, Goldstein M, Moel D, Dikman S, Guttenplan J. Cisplatin nephrotoxicity. Am J Kidney Dis. 1986:8:356-67.
  11. Salahudeen A, Badr K, Morrow J, Roberts J 2nd. Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells. J Am Soc Nephrol. 1995:6:1300-3.
  12. Masuda H, Tanaka T, Takahama U. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system. Biochem Biophys Res Commun. 1994:203:1175-80. https://doi.org/10.1006/bbrc.1994.2306
  13. Kuhlmann MK, Burkhardt G, Kohler H. Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application. Nephrol Dial Transplant. 1997:12:2478-80. https://doi.org/10.1093/ndt/12.12.2478
  14. Cetin R, Devrim E, Kilicoglu B, Avci A, Candir O, Durak I. Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods. J Appl Toxicol. 2006:26:42-6. https://doi.org/10.1002/jat.1103
  15. Ahn H, Lee E, Kim K, Lee C. Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines. J Urol. 1994:151:263-7.
  16. Baldew GS, McVie JG, van der Valk MA, Los G, de Goeij JJ, Vermeulen NP. Selective reduction of cisdiamminedichloropla-tinum(II) nephrotoxicity by ebselen Cancer Res. 1990:50:7031-6.
  17. Kang DG, Lee AS, Mun YJ, Woo WH, Kim YC, Sohn EJ, Moon MK, Lee HS. Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats. Biol Pharm Bull. 2004:27:366-70. https://doi.org/10.1248/bpb.27.366
  18. Gordon JA, Peterson LN, Anderson RJ. Water metabolism after cisplatin in the rat. Am J Physiol. 1982:243:36-43.
  19. Seguro AC, Shimizu MH, Kudo LH, dos Santos Rocha A. Renal concentration defect induced by cisplatin. The role of thick ascending limb and papillary collecting duct. Am J Nephrol. 1989:9:59-65. https://doi.org/10.1159/000167938
  20. Suzuki CA, Cherian MG. The interactions of cis-diamminedichloroplatinum with metallothionein and glutathione in rat liver and kidney. Toxicology. 1990:64:113-27. https://doi.org/10.1016/0300-483X(90)90129-5
  21. Wong NL, Walker VR, Wong EF, Sutton RA. Mechanism of polyuria after cisplatin therapy. Nephron. 1993:65:623-7. https://doi.org/10.1159/000187575
  22. Lieberthal W, Triaca V, Levine J. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis. Am J Physiol. 1996:270:700-8.
  23. Davis CA, Nick HS, Agarwal A. Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol. 2001:12:2683-90.
  24. Karimi G, Ramezani M, Tahoonian Z. Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evid Based Complement Alternat Med. 2005:2:383-6. https://doi.org/10.1093/ecam/neh103
  25. Shimeda Y, Hirotani Y, Akimoto Y, Shindou K, Ijiri Y, Nishihori T, Tanaka K, Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biol Pharm Bull. 2005;28:1635-8. https://doi.org/10.1248/bpb.28.1635
  26. Latha PG, Panikkar KR. Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice. Phytother Res. 2001;15:364-6. https://doi.org/10.1002/ptr.727
  27. Duarte, C.G., dos Santos, G.L., Azzolini, A.E. and de Assis Pandochi, A.I. The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats. Int. J. Immunopharmacol; 2000, p. 22, 25-33. https://doi.org/10.1016/S0192-0561(99)00061-2
  28. Yu SJ, Tseng J. Fu-Ling, a Chinese herbal drug, modulates cytokine secretion by human peripheral blood monocytes. Int J Immunopharmacol. 1996:18:37-44. https://doi.org/10.1016/0192-0561(95)00103-4
  29. Mansour MA, Mostafa AM, Nagi MN, Khattab MM, Al-Shabanah OA. Protective effect of aminoguanidine against nephrotoxicity induced by cisplatin in normal rats. Comp Biochem Physiol C Toxicol Pharmacol. 2002:132:123-8. https://doi.org/10.1016/S1532-0456(02)00062-5
  30. Sodikoff CH. Laboratory profiles of small animal diseases. A guide to laboratory diagnosis. 2nd ed., Mosby: St. Louise: 1995, p. 1-36.
  31. Kim YK, Choi TR, Kwon CH, Kim JH, Woo JS, Jung JS. Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. Ren Fail. 2003:25:909-22. https://doi.org/10.1081/JDI-120026026
  32. Gonzalez R, Borrego A, Zamora Z, Romay C, Hernandez F, Menendez S, Montero T, Rojas E. Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats. Mediators Inflamm. 2004:13:307-12. https://doi.org/10.1080/09629350400008836
  33. Matsushima H, Yonemura K, Ohishi K, Hishida A. The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. J Lab Clin Med. 1998:131:518-26. https://doi.org/10.1016/S0022-2143(98)90060-9
  34. Schinella GR, Tournier HA, Prieto JM, Mordujovich de Buschiazzo P, Rios JL. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 2002:70:1023-33. https://doi.org/10.1016/S0024-3205(01)01482-5
  35. Joannidis M. Medical therapy of acute kidney injury. Acta Clin Belg Suppl; 2007, p. 353-6.
  36. Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. J Agric Food Chem. 2007:55:10150-5. https://doi.org/10.1021/jf0723965
  37. Yasukawa K, Kaminaga T, Kitanaka S, Tai T, Nunoura Y, Natori S, Takido M. 3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect. Phytochemistry. 1998:48:1357-60. https://doi.org/10.1016/S0031-9422(97)01063-7
  38. Yamahara J, Takagi Y, Sawada T, Fujimura H, Shirakawa K, Yoshikawa M, Kitagawa I. Effects of crude drugs on congestive edema. Chem Pharm Bull (Tokyo). 1979:27:1464-8. https://doi.org/10.1248/cpb.27.1464