Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지
DOI QR코드

DOI QR Code

NF-${\kappa}B$ Activation by Compounds Found in Platycodon grandiflorum Extract

  • Hong, Sung-Won (Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University) ;
  • Yong, Yeon-Joong (Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University) ;
  • Kang, Kyung-Rai (Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University) ;
  • Shin, Soon-Young (Institute of Biomedical Science and Technology, RCTC, Konkuk University) ;
  • Lee, Young-Han (Institute of Biomedical Science and Technology, RCTC, Konkuk University) ;
  • Lim, Yoong-Ho (Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University)
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-${\kappa}B$). In its active state, NF-${\kappa}B$ turns on the expression of genes related to cell proliferation or death. NF-${\kappa}B$ activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-${\kappa}B$ had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-${\kappa}B$.

Keywords

References

  1. Aderbal, F., M. D. M. Vieira, E. G. Magalhaes, and G. J. Shepherd. 1998. C14 polyacetylenes from Brazilian lobelioideae. Phytochemistry 27: 3827-3830 https://doi.org/10.1016/0031-9422(88)83026-7
  2. Choi, B. H., C. G. Kim, Y. Lim, S. Y. Shin, and Y. H. Lee. 2008. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFjB pathway. Cancer Lett. 259: 111-118 https://doi.org/10.1016/j.canlet.2007.10.003
  3. Copley, R. R., M. Totrov, J. Linnell, S. Field, J. Ragoussis, and I. A. Udalova. 2007. Functional conservation of Rel binding sites in drosophilid genomes. Genome Res. 17: 1327-1335 https://doi.org/10.1101/gr.6490707
  4. Ishimaru, K., H. Yonemitsu, and K. Shimomura. 1991. Lobetyolin and lobetyol from hairy root culture of Lobelia inflata. Phytochemistry 30: 2255-2257 https://doi.org/10.1016/0031-9422(91)83624-T
  5. Malone, P. E. and M. R. Hernandez. 2007. 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. Exp. Eye Res. 84: 444-454 https://doi.org/10.1016/j.exer.2006.10.020
  6. Rayet, B. and C. Gélinas. 1999. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938-6947 https://doi.org/10.1038/sj.onc.1203221
  7. Shin, C., H. Lim, S. Moon, S. Kim, Y. Yong, B. Kim, C. Lee, and Y. Lim. 2006. A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp. Bioorg. Med. Chem. Lett. 16: 5643-5645 https://doi.org/10.1016/j.bmcl.2006.08.015
  8. Sun, X. F. and H. Zhang. 2007. NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol. Histopathol. 22:1387-1398
  9. Yoo, K. Y., O. K. Park, I. K. Hwang, H. Li, S. Y. Ryu, I. J. Kang, et al. 2008. Induction of cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus by aqueous extract from Platycodon grandiflorum in middle-aged mice. Neurosci. Lett. Jul 25. (Epub ahead of print.)

Cited by

  1. Platycoside O, a New Triterpenoid Saponin from the Roots of Platycodon grandiflorum vol.16, pp.6, 2009, https://doi.org/10.3390/molecules16064371