동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제20권1호
  • /
  • Pages.59-73
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  • 2009
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

온담탕합총명탕(溫膽湯合聰明湯) 연수추출물과 초미세분말이 cytokine과 건망증 생쥐모델 기억력감퇴에 미치는 영향

The Effects of Ondam-tanghapChongmyung-tang(Wendantanghecongmingtang) Hot Water Extract & Ultra-fine Powder on Proinflammatory Cytokine of Microglia and Memory Deficit Model

  • 장영주 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실)
  • Jang, Young-Joo (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Jung, In-Chul (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Lee, Sang-Ryong (Dept. of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 발행 : 2009.03.30
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초록

Objectives : This experiment was designed to investigate the effect of the ODTCMT hot water extract & ultra-fine Powder on Alzheimer's Disease Model Induced by 13A. Methods : The effects of the ODTCMT hot water extract on expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the ODTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results : 1. The ODTCMT hot water extract significantly suppressed the production of TNF-${\alpha}$, IL-6 and IL-l${\beta}$ in BV2 microglial cell line treated with LPS. 2. The ODTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions : These results suggest that the ODTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the ODTCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

키워드

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