동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제20권1호
  • /
  • Pages.43-57
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  • 2009
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

환소단(還少丹)이 microglia 염증반응 cytokine과 건망증 생쥐모델에 미치는 영향

The Effects of Hwanso-dan(Huanshaodan) Hot Water Extract & Ultra-fine Powder on Cytokine and Memory Deficit Model

  • 윤종천 (대전대학교 한의과대학 신경정신과교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과교실) ;
  • 정인철 (대전대학교 둔산한방병원)
  • Yoon, Jong-Cheon (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Daejeon University) ;
  • Lee, Sang-Ryong (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Daejeon University) ;
  • Jung, In-Chul (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Daejeon University)
  • 발행 : 2009.03.30
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초록

Objectives : This experiment was designed to investigate the effect of the Hwanso-dan hot water extract & ultra-fine powder on microglia and memory deficit model Methods : The effects of the Hwanso-dan hot water extract on expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ mRNA and production of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by lipopolysacchaide were investigated. The effects of the Hwanso-dan hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and uric acid & AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results : 1. The Hwanso-dan hot water extract suppressed the expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ mRNA in BV2 microglial cell line treated by lipopolysacchaide. 2. The Hwanso-dan hot water extract suppressed the production of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line. 3. The Hwanso-dan hot water extract & ultra-fine powder decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. 4. The Hwanso-dan hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine${\sim}$induced impairment of memory in the experiment of Morris water maze. Conclusions : This experiment shows that the Hwanso-dan hot water extract & ultra-fine powder might be effective for the prevention and treatment of Memory deficit disease. Investigation into the clinical use of the Hwanso-dan hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

키워드

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