Molecular & Cellular Toxicology

  • 제5권2호
  • /
  • Pages.165-171
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  • 2009
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  • 1738-642X(pISSN)
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  • 2092-8467(eISSN)
대한독성유전 단백체학회 (The Korean Society of Toxicogenomics and Toxicoproteomics)
권호 표지

Possible Biomarker Gene for Radiation Workers in Hospital

  • Jin, Young-Woo (Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd) ;
  • Jeong, Mee-Seon (Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd) ;
  • Moon, Kien (Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd) ;
  • Lee, Chee-Young (Hanil General Hospital) ;
  • Bae, Sang-Woo (Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences) ;
  • Choi, Soo-Yong (Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Yun-Sil (Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences)
  • 발행 : 2009.06.30
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초록

Biomarkers indicating past exposure to radiation have not yet been entirely satisfactory. In this study, we validated several genes reported as radiation response genes, as biomarkers to detect past exposure to radiation in occupationally exposed workers, especially workers in the medical field. A total of 54 radiation workers in hospital were investigated for radiation exposure dose. Their average radiation dose of recent one year was 1.09 mSv ($\pm$1.63) with a 10.63 mSv ($\pm$12.91) cumulative dose. The results of the multiple regression analysis for the various variables indicate that the Hsc70 (P=0.0292) and ORAL (P=0.0045) may be candidate biomarkers for the recent 1 year radiation exposure in radiation workers, whereas AEN (P=0.0334) and PGAMI (P=0.0003) might be for cumulative exposure.

키워드

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