Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Study of the Efficacy of Korean Red Ginseng in the Treatment of Androgenic Alopecia

고려 홍삼의 탈모증 개선 효과에 대한 임상 연구

  • Kim, Jae-Hwan (Department of Dermatology, College of Medicine, Korea University) ;
  • Yi, Sang-Min (Department of Dermatology, College of Medicine, Korea University) ;
  • Choi, Jae-Eun (Department of Dermatology, College of Medicine, Korea University) ;
  • Son, Sang-Wook (Department of Dermatology, College of Medicine, Korea University)
  • 김재환 (고려대학교 의과대학 피부과학교실) ;
  • 이상민 (고려대학교 의과대학 피부과학교실) ;
  • 최재은 (고려대학교 의과대학 피부과학교실) ;
  • 손상욱 (고려대학교 의과대학 피부과학교실)
  • Published : 2009.09.30
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Abstract

Alopecia is a common form of hair loss in both male and female, affecting approximately ten million Koreans. Although medical treatments have been developed to treat alopecia, these treatments still have limitations due to complications that come with these treatments. In contrast, Korean red ginseng has been shown to have a stimulating effect on hair follicle and it has already been added to hair treatment products as a safe ingredient. This study was conducted to objectively evaluate the efficacy of Korean red ginseng in the treatment of alopecia. 40 patients suffering from androgenic alopecia were recruited and randomly divided into the experimental (20 patients) and control (20 patients) groups. The experimental group took Korean red ginseng extract (3,000 mg/day) for 24 weeks while the control group took a placebo. The changes of hair counts, thickness, and density were evaluated with Folliscope$^{(R)}$. Patient satisfaction was evaluated through a questionnaire, and clinical photographs were rated by dermatologists. The result of the study showed that Korean red ginseng effectively increased hair density and thickness. Patient satisfaction and evaluation of photographs by dermatologists also confirmed the effectiveness of Korean red ginseng in the treatment of alopecia.

총 32 명의 남성형 및 여성형 탈모 환자를 대상으로 24주 동안 이중 맹검 위약 비교 임상 시험을 시행한 결과 고려 홍삼 분말을 복용한 치료군이 대조군에 비해 통계적으로 유의하게 모발의 밀도와 굵기가 증가하는 것을 객관적으로 확인할 수 있었으며 환자 만족도 평가에서도 역시 치료군이 대조군 보다 높은 만족도를 보였다. 따라서 고려 홍삼의 복용이 임상적으로 탈모증 개선에 큰 도움이 될 것으로 사료된다.

Keywords

References

  1. Paik JK, Yoon JB, Sim WY, Kim BS, Kim NI. The prevalence and types of androgenetic alopecia in Korean men and women. Br J Dermatol. 145: 95-99 (2001) https://doi.org/10.1046/j.1365-2133.2001.04289.x
  2. Arca E, Acikgoz G, Ta tan HB, Kose O, Kurumlu Z. An open, randomized, comparative study of oral finasteride and 5% topicalminoxidil in male androgenetic alopecia. Dermatol. 209: 117-125 (2004) https://doi.org/10.1159/000079595
  3. Lucky AW, Piacquadio DJ, Ditre CM, Dunlap F, Kantor I, Pandya AG, Savin RC, Tharp MD. A randomized, placebocontrolled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol. 50: 541-553 (2004) https://doi.org/10.1016/j.jaad.2003.06.014
  4. Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS. The importance of dual 5$\alpha$-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol. 55: 1014-1023 (2006) https://doi.org/10.1016/j.jaad.2006.05.007
  5. Sinclair R, Wewerinke M, Jolley D. Treatment of female pattern hair loss with oral antinadrogens. Br J Dermatol. 152:466-473 (2005) https://doi.org/10.1111/j.1365-2133.2005.06218.x
  6. Kim SH, Jeong KS, Ryu SY, Kim TH. Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice. In Vivo 12: 219-222 (1998)
  7. Matsuda H, Yamazaki M, Asanuma Y, Kubo M. Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follocles. Phytother Res. 17: 797-800 (2003) https://doi.org/10.1002/ptr.1241
  8. Yang JP, Yeo IS. A study on the true nature of 'Chinese jinseng'. Uisahak 12: 144-166 (2003)
  9. Thatte U, Bagadey S, dahanukar S. Modulation of programmed cell death by medicinal plants. Cell Mol Biol (Noisy-le-grand). 46: 199-214 (2000)
  10. Bae EA, Han MJ, Shin YW, Kim DH. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull. 29: 1862-1867 (2006) https://doi.org/10.1248/bpb.29.1862
  11. Hanneken S, Ritzmann S, Nöthen MM, Kruse R. Androgenetic alopecia: current aspects of a common phenotype. Hautarzt 54: 703-712 (2003) https://doi.org/10.1007/s00105-003-0561-y
  12. Norwood OT. Male pattern baldness: classification and incidence. South Med J 68: 1359-1365 (1975) https://doi.org/10.1097/00007611-197511000-00009

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