Effects of Rice Added with Mulberry Leaves and Fruit on Blood Glucose, Body Fat and Serum Lipid Levels in Rats

뽕잎오디쌀이 흰쥐의 혈당농도와 체지방 및 혈청지질 분획에 미치는 영향

This study was performed to investigate the effects of rice added with mulberry leaves and fruit on blood glucose, body fat and serum lipid levels in Sprague-Dawley male rats for 4 weeks. Mulberry rice diet was prepared with mixture of 50% of purified AIN-diet and 50% of formulated rice consisting of soybean, barley, polished rice, black rice, uncleaned rice bud, mulberry leaves and fruit. The experimental animals were fed the mulberry rice diet (group A) and the purified AIN-diet (group B, diabetic control) for 4 weeks in rats injected with streptozotocin. In terms of observing hypolipidemic effect of mulberry rice, rats were fed either high-fat diet (13% fat) with additional lard, corn oil, cholesterol to AIN-diet (group C, control) or mulberry rice diet mixed with high fat diet (group D) for 4 weeks. Blood glucose level at the 4th week of group A had increased 5 mg/dL compared with that of day 0, while group B increased 51 mg/dL. However, the glucose levels of the groups A and B at the final day were 156 mg/dL (12.4% decrease compared with B) and 178 mg/dL, respectively. As for hypolipidemic effect, weight gain and body fat were 8% lower in the group D and serum triglyceride level also 19% lower in the group D compared with those of group C (p<0.05).

재성형 뽕잎오디혼합쌀 개발과 관련하여 당뇨유발쥐와 고지방식이를 급여한 흰쥐에게 뽕잎오디쌀이 혈당농도와 체지방 및 혈청 지질 농도 등에 미치는 영향을 조사하였다. 혈당실험에서 뽕잎오디쌀조성물은 곡류와 잡곡류 등 85%, 뽕잎과 오디즙 15%로 구성하였고, AIN-diet와 50:50 비율로 혼합하여 4주간 급여한 결과 뽕잎오디쌀 급여군은 당뇨대조군보다 실험종료 시 체중은 28% 증가한 반면 공복혈당치는 12.4%, 혈청 중성지방 농도는 34% 감소하였다(p<0.05). 지질실험의 경우 4주 동안 고지방식이(50%)와 뽕잎오디쌀조성물(50%)의 혼합식이와 고지방식이(50%)와 기본식이(50%)의 혼합식이를 급여한 결과 뽕잎오디쌀 급여군은 고지방대조군에 비해 체중과 체지방(EFP)이 각각 8%씩 낮았고, 혈청 중성지방 농도는 약 19% 감소하였다(p<0.05). 이상에서 뽕잎오디쌀식이는 혈당저하 및 중성지방을 감소시키는 것으로 나타났고, 유의성은 없었으나 다소간 체중과 체지방 감소 효과를 확인할 수 있었다.