Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Human rhinoviruses and asthma in children

  • Kim, Woo Kyung (Department of Pediatrics, Inje University, College of Medicine)
  • Received : 2010.01.04
  • Accepted : 2010.01.14
  • Published : 2010.02.15
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Abstract

Human rhinoviruses (HRVs) is a nonenveloped, single stranded RNA virus belonging to the family Picornavirudae. Transmission by direct contact such as hand-to-hand, hand-to-nose, and hand-to-eye has been readily demonstrated in experimental settings. HRV are the most frequent causes of common cold infection, however, they are also known to replicate in the lower respiratory tract and associated with more severe respiratory illnesses such as asthma. New technique such as reverse transcriptase polymerase chain reaction and molecular typing in HRV has been developed and our understanding of the importance of these respiratory viruses. HRVs consisted of 101 serotypes that are classified into groups A and B according to sequence variations. And there is a newly identified set of HRVs, called Group C, and it is currently under investigation. In recent study using PCR techniques, HRVs accounted for approximate 50-80% of common colds and 85 % of childhood asthma exacerbations and in more than half of adult exacerbations. However, the mechanisms of HRV- induced asthma exacerbations are poorly understood. This review discusses the association between HRVs and childhood asthma.

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References

  1. Gwaltney JM, Jr., Hendley JO. Transmission of experimental rhinovirus infection by contaminated surfaces. Am J Epidemiol 1982;116:828-33
  2. Gwaltney JM, Jr. Epidemiology of the common cold. Ann N Y Acad Sci 1980;353:54-60 https://doi.org/10.1111/j.1749-6632.1980.tb18905.x
  3. Pancic F, Carpentier DC, Came PE. Role of infectious secretions in the transmission of rhinovirus. J Clin Microbiol 1980;12:567-71
  4. Larson HE, Reed SE, Tyrrell DA. Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J Med Virol 1980;5:221-9 https://doi.org/10.1002/jmv.1890050306
  5. Riski H, Hovi T. Coronavirus infections of man associated with diseases other than the common cold. J Med Virol 1980;6:259-65 https://doi.org/10.1002/jmv.1890060309
  6. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. Bmj 1995;310:1225-9
  7. Balfour-Lynn IM, Valman HB, Stanway G, Khan M. Use of polymerase chain reaction to detect rhinovirus in wheezy infants. Arch Dis Child 1992;67:760
  8. Nokso-Koivisto J, Raty R, Blomqvist S, Kleemola M, Syrjanen R, Pitkaranta A, et al. Presence of specific viruses in the middle ear fluids and respiratory secretions of young children with acute otitis media. J Med Virol 2004;72:241-8 https://doi.org/10.1002/jmv.10581
  9. Arola M, Ziegler T, Ruuskanen O, Mertsola J, Nanto-Salonen K, Halonen P. Rhinovirus in acute otitis media. J Pediatr 1988;113:693-5 https://doi.org/10.1016/S0022-3476(88)80380-9
  10. Pitkaranta A, Starck M, Savolainen S, Poyry T, Suomalainen I, Hyypia T, et al. Rhinovirus RNA in the maxillary sinus epithelium of adult patients with acute sinusitis. Clin Infect Dis 2001;33:909-11 https://doi.org/10.1086/322678
  11. Louie JK, Yagi S, Nelson FA, Kiang D, Glaser CA, Rosenberg J, et al. Rhinovirus outbreak in a long term care facility for elderly persons associated with unusually high mortality. Clin Infect Dis 2005;41:262-5 https://doi.org/10.1086/430915
  12. Gern JE, Busse WW. Relationship of viral infections to wheezing illnesses and asthma. Nat Rev Immunol 2002;2:132-8 https://doi.org/10.1038/nri725
  13. Lemanske RF, Jr., Jackson DJ, Gangnon RE, Evans MD, Li Z, Shult PA, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005;116:571-7 https://doi.org/10.1016/j.jaci.2005.06.024
  14. Lee BE, Robinson JL, Khurana V, Pang XL, Preiksaitis JK, Fox JD. Enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests. J Med Virol 2006;78:702-10 https://doi.org/10.1002/jmv.20595
  15. Singleton RJ, Wirsing EA, Haberling DL, Christensen KY, Paddock CD, Hilinski JA, et al. Risk factors for lower respiratory tract infection death among infants in the United States, 1999-2004. Pediatrics 2009;124:e768-76 https://doi.org/10.1542/peds.2009-0109
  16. Kumar A, Grayson MH. The role of viruses in the development and exacerbation of atopic disease. Ann Allergy Asthma Immunol 2009;103:181-6 https://doi.org/10.1016/S1081-1206(10)60178-0
  17. Pelon W, Mogabgab WJ, Phillips IA, Pierce WE. A cytopathogenic agent isolated from naval recruits with mild respiratory illnesses. Proc Soc Exp Biol Med 1957;94:262-7
  18. Price WH. The Isolation of a New Virus Associated with Respiratory Clinical Disease in Humans. Proc Natl Acad Sci U S A 1956;42:892-6 https://doi.org/10.1073/pnas.42.12.892
  19. Hamparian VV, Colonno RJ, Cooney MK, Dick EC, Gwaltney JM, Jr., Hughes JH, et al. A collaborative report: rhinoviruses-- extension of the numbering system from 89 to 100. Virology 1987;159:191-2 https://doi.org/10.1016/0042-6822(87)90367-9
  20. Hayden FG. Rhinovirus and the lower respiratory tract. Rev Med Virol 2004;14:17-31 https://doi.org/10.1002/rmv.406
  21. Lee WM, Monroe SS, Rueckert RR. Role of maturation cleavage in infectivity of picornaviruses: activation of an infectosome. J Virol 1993;67:2110-22
  22. Gwaltney JM, Jr., Hendley JO. Rhinovirus transmission: one if by air, two if by hand. Am J Epidemiol 1978;107:357-61
  23. Gwaltney JM, Jr., Moskalski PB, Hendley JO. Hand-to-hand transmission of rhinovirus colds. Ann Intern Med 1978;88:463-7
  24. Winther B, Gwaltney JM, Hendley JO. Respiratory virus infection of monolayer cultures of human nasal epithelial cells. Am Rev Respir Dis. 1990;141:839-45
  25. Fox JP, Cooney MK, Hall CE. The Seattle virus watch. V. Epidemiologic observations of rhinovirus infections, 1965- 1969, in families with young children. Am J Epidemiol 1975;101:122-43
  26. Jarjour NN, Gern JE, Kelly EA, Swenson CA, Dick CR, Busse WW. The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils. J Allergy Clin Immunol 2000;105:1169-77 https://doi.org/10.1067/mai.2000.106376
  27. Johnston SL, Papi A, Bates PJ, Mastronarde JG, Monick MM, Hunninghake GW. Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium. J Immunol 1998;160:6172-81
  28. Laza-Stanca V, Stanciu LA, Message SD, Edwards MR, Gern JE, Johnston SL. Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production. J Virol 2006;80:8248-58 https://doi.org/10.1128/JVI.00162-06
  29. Chung JY, Han TH, Kim SW, Kim CK, Hwang ES. Detection of viruses identified recently in children with acute wheezing. J Med Virol 2007;79:1238-43 https://doi.org/10.1002/jmv.20926
  30. Loens K, Goossens H, de Laat C, Foolen H, Oudshoorn P, Pattyn S, et al. Detection of rhinoviruses by tissue culture and two independent amplification techniques, nucleic acid sequence-based amplification and reverse transcription-PCR, in children with acute respiratory infections during a winter season. J Clin Microbiol 2006;44:166-71 https://doi.org/10.1128/JCM.44.1.166-171.2006
  31. Leung TF, To MY, Yeung AC, Wong YS, Wong GW, Chan PK. Multiplex Molecular Detection of Respiratory Pathogens in Children with Asthma Exacerbation. Chest 2010;137:348-54 https://doi.org/10.1378/chest.09-1250
  32. Elnifro EM, Ashshi AM, Cooper RJ, Klapper PE. Multiplex PCR: optimization and application in diagnostic virology. Clin Microbiol Rev 2000;13:559-70 https://doi.org/10.1128/CMR.13.4.559-570.2000
  33. Sung RY, Chan PK, Tsen T, Li AM, Lam WY, Yeung AC, et al. Identification of viral and atypical bacterial pathogens in children hospitalized with acute respiratory infections in Hong Kong by multiplex PCR assays. J Med Virol. 2009;81:153-9 https://doi.org/10.1002/jmv.21364
  34. Spyridaki IS, Christodoulou I, de Beer L, Hovland V, Kurowski M, Olszewska-Ziaber A, et al. Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN project. J Virol Methods 2009;156:102-6 https://doi.org/10.1016/j.jviromet.2008.10.027
  35. Lee WM, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T, et al. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS ONE 2007;2:e966 https://doi.org/10.1371/journal.pone.0000966
  36. McErlean P, Shackelton LA, Andrews E, Webster DR, Lambert SB, Nissen MD, et al. Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C). PLoS ONE 2008;3:e1847 https://doi.org/10.1371/journal.pone.0001847
  37. Dominguez SR, Briese T, Palacios G, Hui J, Villari J, Kapoor V, et al. Multiplex MassTag-PCR for respiratory pathogens in pediatric nasopharyngeal washes negative by conventional diagnostic testing shows a high prevalence of viruses belonging to a newly recognized rhinovirus clade. J Clin Virol 2008;43:219-22 https://doi.org/10.1016/j.jcv.2008.06.007
  38. Kistler A, Avila PC, Rouskin S, Wang D, Ward T, Yagi S, et al. Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity. J Infect Dis 2007;196:817-25 https://doi.org/10.1086/520816
  39. Rotbart HA, Hayden FG. Picornavirus infections: a primer for the practitioner. Arch Fam Med 2000;9:913-20 https://doi.org/10.1001/archfami.9.9.913
  40. Arruda E, Pitkaranta A, Witek TJ, Jr., Doyle CA, Hayden FG. Frequency and natural history of rhinovirus infections in adults during autumn. J Clin Microbiol 1997;35:2864-8
  41. Makela MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimaki M, et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol 1998;36:539-42
  42. Gonzales R, Malone DC, Maselli JH, Sande MA. Excessive antibiotic use for acute respiratory infections in the United States. Clin Infect Dis 2001;33:757-62 https://doi.org/10.1086/322627
  43. Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005;171:137-41 https://doi.org/10.1164/rccm.200406-730OC
  44. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999;354:541-5 https://doi.org/10.1016/S0140-6736(98)10321-5
  45. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008;178:667-72 https://doi.org/10.1164/rccm.200802-309OC
  46. Dales RE, Schweitzer I, Toogood JH, Drouin M, Yang W, Dolovich J, et al. Respiratory infections and the autumn increase in asthma morbidity. Eur Respir J 1996;9:72-7 https://doi.org/10.1183/09031936.96.09010072
  47. Sorkness RL, Castleman WL, Kumar A, Kaplan MR, Lemanske RF, Jr. Prevention of chronic postbronchiolitis airway sequelae with IFN-gamma treatment in rats. Am J Respir Crit Care Med 1999;160:705-10
  48. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000;55:1023-7 https://doi.org/10.1136/thorax.55.12.1023
  49. Reijonen TM, Kotaniemi-Syrjanen A, Korhonen K, Korppi M. Predictors of asthma three years after hospital admission for wheezing in infancy. Pediatrics 2000;106:1406-12 https://doi.org/10.1542/peds.106.6.1406
  50. Clough JB, Keeping KA, Edwards LC, Freeman WM, Warner JA, Warner JO. Can we predict which wheezy infants will continue to wheeze? Am J Respir Crit Care Med 1999;160:1473-80
  51. Ehlenfield DR, Cameron K, Welliver RC. Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease. Pediatrics 2000;105:79-83 https://doi.org/10.1542/peds.105.1.79
  52. Koller DY, Wojnarowski C, Herkner KR, Weinlander G, Raderer M, Eichler I, et al. High levels of eosinophil cationic protein in wheezing infants predict the development of asthma. J Allergy Clin Immunol 1997;99:752-6 https://doi.org/10.1016/S0091-6749(97)80007-3
  53. Reijonen TM, Korppi M, Kleemola M, Savolainen K, Kuikka L, Mononen I, et al. Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing. Pediatr Pulmonol 1997;24:35-41 https://doi.org/10.1002/(SICI)1099-0496(199707)24:1<35::AID-PPUL6>3.0.CO;2-I
  54. Renzi PM, Turgeon JP, Yang JP, Drblik SP, Marcotte JE, Pedneault L, et al. Cellular immunity is activated and a TH- 2 response is associated with early wheezing in infants after bronchiolitis. J Pediatr 1997;130:584-93 https://doi.org/10.1016/S0022-3476(97)70243-9
  55. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, et al. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am J Respir Crit Care Med 2000;161:1518-23
  56. Parry DE, Busse WW, Sukow KA, Dick CR, Swenson C, Gern JE. Rhinovirus-induced PBMC responses and outcome of experimental infection in allergic subjects. J Allergy Clin Immunol 2000;105:692-8 https://doi.org/10.1067/mai.2000.104785
  57. Johnston SL, Pattemore PK, Sanderson G, Smith S, Campbell MJ, Josephs LK, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a timetrend analysis. Am J Respir Crit Care Med 1996;154:654-60 https://doi.org/10.1164/ajrccm.154.3.8810601
  58. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376-82 https://doi.org/10.1136/thx.2005.042523
  59. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. Bmj 1993;307:982-6 https://doi.org/10.1136/bmj.307.6910.982
  60. Tsolia MN, Psarras S, Bossios A, Audi H, Paldanius M, Gourgiotis D, et al. Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections. Clin Infect Dis 2004;39:681-6 https://doi.org/10.1086/422996
  61. Chen Y, Hamati E, Lee PK, Lee WM, Wachi S, Schnurr D, et al. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. Am J Respir Cell Mol Biol 2006;34:192-203 https://doi.org/10.1165/rcmb.2004-0417OC
  62. Gern JE, Busse WW. Learning from molecular sleuths. J Allergy Clin Immunol 2009;123:105-6 https://doi.org/10.1016/j.jaci.2008.11.029
  63. Gern JE, Vrtis R, Grindle KA, Swenson C, Busse WW. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med 2000;162:2226-31
  64. Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, Marlor CW, et al. The major human rhinovirus receptor is ICAM-1. Cell 1989;56:839-47 https://doi.org/10.1016/0092-8674(89)90688-0
  65. Bentley AM, Durham SR, Robinson DS, Menz G, Storz C, Cromwell O, et al. Expression of endothelial and leukocyte adhesion molecules interacellular adhesion molecule-1, Eselectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergen-induced asthma. J Allergy Clin Immunol 1993;92:857-68 https://doi.org/10.1016/0091-6749(93)90064-M
  66. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax 2002;57:328-32 https://doi.org/10.1136/thorax.57.4.328
  67. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects. Clin Exp Allergy 2002;32:537-42 https://doi.org/10.1046/j.0954-7894.2002.01313.x
  68. Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 2002;359:831-4 https://doi.org/10.1016/S0140-6736(02)07953-9
  69. Ghildyal R, Dagher H, Donninger H, de Silva D, Li X, Freezer NJ, et al. Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor. J Med Virol 2005;75:608-15 https://doi.org/10.1002/jmv.20315
  70. De Silva D, Dagher H, Ghildyal R, Lindsay M, Li X, Freezer NJ, et al. Vascular endothelial growth factor induction by rhinovirus infection. J Med Virol 2006;78:666-72 https://doi.org/10.1002/jmv.20591
  71. Turner RB, Weingand KW, Yeh CH, Leedy DW. Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Clin Infect Dis 1998;26:840-6 https://doi.org/10.1086/513922
  72. Spurrell JC, Wiehler S, Zaheer RS, Sanders SP, Proud D. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 2005;289:L85-95 https://doi.org/10.1152/ajplung.00397.2004
  73. Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996;153: 530-4
  74. Wark PA, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2002;19:68-75 https://doi.org/10.1183/09031936.02.00226302

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