Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Stability of Nano-Emulsions Prepared by Solubilization Method

가용화법에 의해 제조된 나노에멀젼의 안정성

  • 이동렬 (LG 생활건강기술원 화장품연구소) ;
  • 조완구 (전주대학교 대체의학대학 기초의과학과)
  • Received : 2010.11.03
  • Accepted : 2010.12.13
  • Published : 2010.12.30
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Abstract

In this study, we varied emulsifiers and oils for obtaining nano-emulsions with low viscosity using solubilization method. We obtained the stable nano-emulsions with 100 nm droplet size composed with hexyl laurate, ceteareth-20, PEG-40 hydrogenated caster oil, glyceryl stearate, and stearic acid. This nano-emulsion was stable against time. The stability of nano-emulsions was measured through the change of particle size. The cooling process was an important factor for obtaining stable emulsions by solubilization method. Stability of nano-emulions was maximum only when cooled rapidly.

본 연구에서는 가용화법을 이용하여 점도가 낮은 나노에멀젼을 얻기 위해서 계면활성제와 오일을 변화시켰다. 헥실라우레이트, 세테아레스-20, PEG-40 수첨 피마자유, 글리세릴스테아레이트 및 스테아린산을 함유하며 입자 크기가 100 nm 정도 되는 나노에멀젼을 제조할 수 있었다. 이렇게 제조된 에멀젼은 안정하였으며 안정성은 입자의 변화로 측정하였다. 가용화법으로 안정한 나노에멀젼을 얻기 위해서는 에멀젼을 제조한 후 냉각과정이 중요한 변수로 작용하였다. 냉각과정을 신속하게 진행하였을 때 최대의 안정성을 보였다.

Keywords

References

  1. J. Ugelstadt, M. S. El-Aassar, and J. W. Vanderhoff, Emulsion polymerization: initiation of polymerization in monomer droplets, J. Polym. Sci., 11, 503 (1973).
  2. W. G. Cho, H. J. Yang, and S. N. Park, Ostwald ripening in hydrogenated lecithin-stabilized oil-inwater nano-emulsions, J. Korean Cosmet. Sci., 34(1), 9 (2008).
  3. H. J. Yang, W. G. Cho, and S. N. Park, Stability of oil-in-water emulsions prepared using the phase inversion composition method, J. of Ind. Eng. Chem., 15. 331 (2009). https://doi.org/10.1016/j.jiec.2009.01.001
  4. H. J. Yang, J. H. Kim, W. G. Cho, and S. N. Park, The stability of emulsions formed by phase inversion with variation of HLB of surfactant, J. of Korean Oil Chemist' Soc., 26(2), 117 (2009).
  5. B. P. Binks, W. G. Cho, P. D. I. Fletcher, and D. N. Petsev, Stability of oil-in-water emulsions in a low interfacial tension system, Langmuir, 16, 1025 (2000). https://doi.org/10.1021/la990952m
  6. S. Sajjadi, Effect of mixing protocol on formation of fine emulsions, Chem. Eng. Sci., 61, 3009 (2006). https://doi.org/10.1016/j.ces.2005.10.071
  7. S. K. Sahoo and V. Labhasetwar, Nanotech approaches to drug delivery and imaging, DDT, 8(24), 1112 (2003). https://doi.org/10.1016/S1359-6446(03)02903-9
  8. G. Orive, R. M. Hernandez, A. R. Gascon, A. Dominguez-Gil, and J. L. Pedraz, Drug delivery in biotechnology: present and future, Curr. Opin. Biotechnol., 14, 659 (2003). https://doi.org/10.1016/j.copbio.2003.10.007
  9. K. Y. Kyong, U. K. Jee, and W. G. Cho, Preparation and evaluation of cubic liquid crystalline phase gel and cubosome containing polyethoxylated retinamide, J. Kor. Pharm. Sci., 37(2), 85 (2007).
  10. T. J. Mason, J. N. Wilking, K. Meleson, C. B. Chang, and S. M. Graves, Nanoemulsion: formation, structure and physical properties, J. Phys. Condens. Matter, 18, 635 (2006). https://doi.org/10.1088/0953-8984/18/41/R01
  11. P. Izquierdo, J. Esquena, Th. F. Tadros, C. Dederen, M. J. Garcia, N. Azemar, and C. Solans, Formation and stability of nano-emulsions, Langmuir, 18, 26 (2002). https://doi.org/10.1021/la010808c
  12. E. Esposito, M. Drechsler, P. Mariani, E. Sivieri, R. Bozzini, L. Montesi, E. Menegatti, and R. Cortesi, Nanosystems for skin hydration: a comparative study, Int. J. of Cosmetic Sci., 29, 39 (2007). https://doi.org/10.1111/j.1467-2494.2007.00362.x
  13. W. G. Cho, Cosmetic emulsions: stabilization by particles, J. Korean Cosmet. Sci., 36(1), 1 (2010).
  14. I. Cuellar, J. Bullon, A. M. Forgarini, A. Cardenas, and M. I. Briceno, More efficient preparation of parenteral emulsions or how to improve a pharmaceutical recipe by formulation engineering, Chem. Eng. Sci., 60, 2127 (2005). https://doi.org/10.1016/j.ces.2004.11.013
  15. W. G. Cho and S. J. Kim, Formation of skin lotions using various vehicles and skin hydration effects for a skin, J. of Korean Oil Chemist' Soc., 26(2), 124 (2009).
  16. D. S. Seo, J. C. Kim, H. H. Sohn, W. G. Cho, S. U. Lee, E. Y. Kim, Y. T. Gi, S. Y. Lee, and H. Y. Lee, Two-dimensional packing parameters of amino acid surfactant and higher alcohols in an aqueous phase and their associated packing parameters, J. Colloid Interface Sci., 273, 596 (2004). https://doi.org/10.1016/j.jcis.2004.01.004
  17. U. S. Patent 0160651 (2007).