Journal of Oral Medicine and Pain

  • 제35권4호
  • /
  • Pages.237-243
  • /
  • 2010
  • /
  • 2288-9272(pISSN)
  • /
  • 2383-8493(eISSN)
대한안면통증구강내과학회 (Korean Academy of Orofacial Pain and Oral Medicine)
권호 표지

구강내 개화성 유두종증을 가진 악성 흑색극세포증의 증례보고

Malignant Acanthosis Nigricans with Oral Florid Papillomatosis ; A Case Report

  • 정재광 (경북대학교 치의학전문대학원 구강내과학교실) ;
  • 신홍인 (경북대학교 치의학전문대학원 구강병리학교실) ;
  • 민보경 (경북대학교 치의학전문대학원 구강내과학교실)
  • Jung, Jae-Kwang (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Shin, Hong-Ihn (Department of Oral Pathology, School of Dentistry, Kyungpook National University) ;
  • Min, Bo-Kyung (Department of Oral Medicine, School of Dentistry, Kyungpook National University)
  • 투고 : 2010.09.12
  • 심사 : 2010.10.15
  • 발행 : 2010.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

흑색극세포증은 대개 피부가 접히는 부위에서 짙은 색의 반점과 함께 벨벳양상을 가진 두꺼워진 피부 그리고 혀, 치은, 점막, 구개를 포함하는 구강내 및 입술부위의 유두종증의 특징을 가진다. 그중에서도 악성 흑색극세포증은 기저 암종과 연관되어 발생되며 특징적으로 입술과 눈꺼풀의 개화성 유두종증, 손바닥 및 발바닥의 저명한 과각화증, 레제르-트렐라 증후와 같은 세가지 특징이 나타난다. 본 증례의 환자에서 악성 흑색극세포증의 전형적인 임상적 그리고 조직학적 특징과 함께 악성 위장 선암종의 병력을 가지고 있었다.

Acanthosis nigricans usually has the characteristics that involve the development of darker pigmented patches and thickened skin with velvety texture on the body folds, and papillomatosis on lip and intraoral regions including tongue, gingiva, mucosa, palate. Malignant acanthosis nigricans, a type of acanthosis nigricans, occurs most commonly in association with underlying malignancy and characterically appears with three characteristic mucocutaneous lesion : especially of the lips and eyelids, hyperkeratosis of the palms and soles, the sign of Leser-Trelat. In the present report, the patient had typical clinical and histological findings of oral acanthosis nigricans, as well as past medical history associated with malignant gastric adenocarcinoma.

키워드

참고문헌

  1. Curth HO. The necessity of distinguishing four type of acanthosis nigricans. In: Jadassohn W, Schirren CG,eds.XIII Congressus Internationalis Dermatologiae 31.7-5.8.1967 Munchen. Berlin: Springer-Verlag, 1968: 557-558.
  2. Pollitzer S. Acanthosis nigricans. In: Unna PG, Morris M, Besnier E, et al., editors. International atlas of rare skin disease. London: HK Lewis&Co, 1890:1-3. Cited in:Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol 1994;31:1-19. https://doi.org/10.1016/S0190-9622(94)70128-8
  3. Pollitzer S. Acanthosis nigricans: a symptom of a disorder of the abdominal sympathetic. JAMA 1909;53:1369-1373.
  4. Curth HO, Hilberg AW, Machacek GF. The site and histology of the cancer associated with malignant acanthosis nigricans. Cancer 1962;15:364-382. https://doi.org/10.1002/1097-0142(196203/04)15:2<364::AID-CNCR2820150220>3.0.CO;2-M
  5. Rogers DL. Acanthosis nigricans. Sem Dermatol 1991;10160-10163.
  6. Kahn CR, Flier JS, Bar RS et al. The syndromes of insulin resistance and acanthosis nigricans: Insulinreceptor disorders in man. N Engl J Med 1976;294: 739-745. https://doi.org/10.1056/NEJM197604012941401
  7. Curth HO. Cancer associated with malignant acanthosis nigricans: review of literature and report of a case of acanthosis nigricans with cancer of the breast. Arch Surg 1943;47:517-552. https://doi.org/10.1001/archsurg.1943.01220180003001
  8. Curth HO. Skin lesions and internal carcinoma. In: Andrade R, Gumport SL, Popkin GL, et al, eds. Cancer of the skin:biology-diagnosis-management. Philadelphia:WB Saunders, 1976:1308-1341.
  9. Gross G, Pfister H, Hellenthal B, et al. Acanthosis nigricans maligna: clinical and virological investigations. Dermatologica 1984;168:265-272. https://doi.org/10.1159/000249721
  10. Ramirez-Amador V, Esquivel-Pedraza L, Caballero- Mendoza E, Berumen-Campos J, Orozco-Topete R, Angeles-Angeles A. Oral manifestations as a hallmark of malignant acanthosis nigricans. J Oral Pathol Med. 1999 Jul;28(6):278-281.
  11. Sedano HO, Gorlin RJ. Acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1987;63:462-467. https://doi.org/10.1016/0030-4220(87)90259-3
  12. Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol 1994;31:1-19. https://doi.org/10.1016/S0190-9622(94)70128-8
  13. Janier M, Blanchet-Bardon C, Bonvalet D, et al. Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma: report of 2 cases. Dermatologica 1988;176:133-137. https://doi.org/10.1159/000248689
  14. Greenwood R, Tring FC. Treatment of malignant acanthosis nigricans with cyproheptadine. Br J Dermatol 1982;106:705-710. https://doi.org/10.1111/j.1365-2133.1982.tb11687.x
  15. Tyler MT, Ficarra G, Silverman S Jr, Odom RB, Regezi JA. Malignant acanthosis nigricans with florid papillary oral lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Apr;81(4):445-449. https://doi.org/10.1016/S1079-2104(96)80021-7
  16. Darmstadt GL, Yokel BK, Horn TD, et al. Treatment of acanthosis nigricans with tretinoin. Arch Dermatol 1991;127:1139-1140. https://doi.org/10.1001/archderm.127.8.1139
  17. Higgins SP, Freemark M, Prose NS. Acanthosis nigricans: a practical approach to evaluation and management. Dermatol Online J. 2008 Sep 15;14(9):2.
  18. Kierland RR. Acanthosis nigricans: an analysis of data in twenty-two cases and a study of its frequency in necropsy material. J Invest Dermatol 1947;9:299-305. https://doi.org/10.1038/jid.1947.102
  19. Zaerko VV. Acanthosis nigricans in patients with stomach cancer. Klin Med (Mosk) 1992;70:50-52.
  20. Ellis DL, Kafka SP, Chow JC, Nanney LB, Inman WH, McCadden ME, et al. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multiple acrochordons. A possible role for alphatransforming growth factor in cutaneous paraneoplastic syndromes. New Engl J Med 1987;317: 1582-1587. https://doi.org/10.1056/NEJM198712173172506