대한방사선기술학회지:방사선기술과학 (Journal of radiological science and technology)

  • 제33권4호
  • /
  • Pages.321-326
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  • 2010
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  • 2288-3509(pISSN)
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  • 2384-1168(eISSN)
대한방사선과학회 (Korean Society of Radiological Science)
권호 표지

알긴산올리고당 처치 마우스의 방사선 유도 IL-6

Radiation-Induced IL(interleukin)-6 in Mice with Algin-Oligosaccharide Treatment

  • 최성관 (광주보건대학 방사선과) ;
  • 지연상 (광주보건대학 방사선과)
  • Choi, Seong-Kwan (Dept. of Radiological Technology, Gwangju Health University) ;
  • Ji, Youn-Sang (Dept. of Radiological Technology, Gwangju Health University)
  • 투고 : 2010.09.28
  • 심사 : 2010.12.03
  • 발행 : 2010.12.31
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초록

본 연구에서는 미역이나 다시마에 많이 분포하면서 항산화작용이 탁월한 알긴산올리고당의 방사선 방어효과를 알아보기 위해 3 Gy 방사선이 전신 1회 조사된 마우스를 가지고 IL-6을 측정하였다. 측정 결과 방사선조사대조군과 비교하여 볼 때 소장과 간 조직 모두 방사선조사 전 7일간 알긴산올리고당의 처치를 시행한 그룹에서 IL-6 생성이 억제됨을 관찰하였다(p < 0.001). 이는 알긴산올리고당이 항산화작용을 통해 방사선이 피폭된 생체조직을 방어함으로써 IL-6의 생성을 억제한 것으로 사료된다. 결론적으로, 본 연구를 통해 알긴산올리고당의 일부 방사선 방어효과를 규명했고 아울러 화학적 독성이 없는 자연산생물이 방사선 방어제로 활용될 수 있을 가능성을 확인하였다.

To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p < 0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin-oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.

키워드

참고문헌

  1. S.K. Choi, W.K. Jung, K.S. Lee, Y.I. Jang, K.R. Dong. "Radioprotective effect of algin-oligosaccharide through measuring caspase-3 and caspase-9 in mice", Journal of radiation protection. Vol. 32, NO. 4: 134-139, 2007
  2. W.Y. Jang, S.K. Choi, K.R. Dong. "Change of the radiation-induced NO(nitric oxide) in mice with treatment by algin-oligosaccharide". Journal of the korea contents association. Vol. 9, NO. 7: 211-217, 2009 https://doi.org/10.5392/JKCA.2009.9.7.211
  3. S.H. Kim, H. Oh, S.E. Lee, J.A. Yang, Y.W. Jung. "Radioprotective effect of red ginseng in irradiated mice with high and low dose of radiation", Korean J. Ginseng Sci. Vol. 22, No 1: 67, 1998
  4. V.K. Singh, V. Srinivasan, T.M. Seed, W.E. Jackson, V.E. Miner, K.S. Kumar. "Radioprotection by N-palmitoylated nonapeptide of human interleukin-1$\beta$." Peptides 26: 413-418, 2005 https://doi.org/10.1016/j.peptides.2004.10.022
  5. P. Fedorocko, N.O. Mackova. "Radioprotection of haemopoietic stem cells by a single injection of bacterial lysate - IRS-19 administered to mice before or after irradiation." International Journal of Immunopharmacology 22: 989-999, 2000 https://doi.org/10.1016/S0192-0561(00)00063-1
  6. G.H.W. Wong. "Protective roles of cytokines against radiation: induction of mitochondrial MnSOD." Biochemeca et Biophysica Acta 1271: 205-209, 1995 https://doi.org/10.1016/0925-4439(95)00029-4
  7. V.K. Singh, V.S. Yadav. "Role of cytokines and growth factors in radioprotection." Experimental and Molecular Pathology 78:156-169, 2005 https://doi.org/10.1016/j.yexmp.2004.10.003
  8. Y.H. Bai, T.H. An, S.C. Lim, et al. "Effect of Alginic Acid on Experimentally Induced Arthropathy in Rabbit Model." Korean J Vet Res 42(2): 153-162, 2002
  9. H. Seki, K. Iwai, H. Kanegane, et al. "Differential protective action of cytokines on radiation-induced apoptosis of peripheral lymphocyte subpopulations." Cellular Immunology 163: 30-36, 1995 https://doi.org/10.1006/cimm.1995.1095
  10. F. Legue, N. Guitton, V. Brouazin-Jousseaume, S. Colleu-Durel, K. Nourgalieva, C. Chenal. "IL-6 a key cytokine in vitro and in vivo response of sertoli cells to external gamma irradiation." CYTOKINE Vol. 16, No. 6: 232-238, 2001 https://doi.org/10.1006/cyto.2001.0970
  11. D. Frasca, P. Barattini, G. Tocchi, et al. "Modulation of X-ray-induced damage recog-nition and repair in ageing human peripheral blood mononuclear cells by an interleukin-6-type cytokine." Mechanisms of Ageing and Development 121:5-19, 2000
  12. A.V. Der Meeren, C. Squiban, P. Gourmelon, H. Lafont, M.H. Gaugler. "Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells." CYTOKINE, Vol. 11, No. 11:831-838, 1999 https://doi.org/10.1006/cyto.1999.0497
  13. H.J. Ross, A.L. Canada, R.J. Antoniono, J.L. Redpath. "High and low dose rate irradiation have opposing effects on cytokine gene expression in human glioblastoma cell lines." European journal of cancer, Vol. 33, No. 1: 144-152, 1997 https://doi.org/10.1016/S0959-8049(96)00341-3