The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Brine Mineral Water on TMA-Induced Contact Hypersensitivity Reaction in the Mouse Model

TMA로 유도된 접촉성 과민 반응 마우스 질환모델에서 해양성 광천수 도포시의 치료효과

  • Kim, Jae-Jin (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University) ;
  • Kim, Wan-Jae (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University) ;
  • Sim, Jae-Man (Gangneung Science Industry Foundation) ;
  • Choi, Seon-Kang (Gangneung Science Industry Foundation) ;
  • Kwon, Soon-Sung (Geumjin Life Science Co., Ltd.) ;
  • Kim, Jung-Duk (Geumjin Life Science Co., Ltd.) ;
  • Lee, Kwang-Ho (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University)
  • 김재진 (건국대학교 의료생명대학 생명공학과) ;
  • 김완재 (건국대학교 의료생명대학 생명공학과) ;
  • 심재만 (강릉과학산업진흥원) ;
  • 최선강 (강릉과학산업진흥원) ;
  • 권순성 ((주)금진 생명과학) ;
  • 김정득 ((주)금진 생명과학) ;
  • 이광호 (건국대학교 의료생명대학 생명공학과)
  • Received : 2010.08.12
  • Accepted : 2010.11.28
  • Published : 2010.12.01
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Abstract

Effect of brine mineral water(BMW) on contact hypersensitivity reaction(CHR) was estimated using trimellitic anhydride (TMA) induced CHR in the mouse. BMW exhibited potent inhibitory activity on TMA induced CHR. BMW treatment suppressed the ear swelling, and attenuated hyper-activated lymph nodes stimulated by TMA challenge, thereby reduced their weight. The immunological index was analyzed after BMW administration in CHR. The level of serum IgE was significantly down regulated after BMW treatment. Furthermore, BMW showed inhibitory property of cytokine production. BMW treatment suppressed not only Th2 type cytokine, IL-4 but also pro-inflammatory cytokines such as TNF-${\alpha}$ and IL-6. From the histological analysis, the inflammatory context appeared by atopic dermatitis lesion after challenging with TMA are diminished by BMW treatment. Our results suggest that BMW may attenuate the development of CHR, and can be available for functional ingredient.

Keywords

References

  1. Chung KT, Lee SH. 2008. Current status of domestic and overseas research of the characteristics and use of deep sea water. Korean J Food & Nutr 21:592-598
  2. Ham SS, Kim SH, Moon SY, Jeon MS, Oh DH, Choi SP. 2005. Antioxidative, antimutagenic and cytotoxic effects of the mineral water. J Fd Hyg Safety 20:53-57
  3. Hataguchi Y, Tai H, Nakajima H, Kimata H. 2005. Drinking deep-sea water restores mineral imbalance in atopic eczema/ dermatitis syndrome. Eur J Clin Nutr 59:1093-1096 https://doi.org/10.1038/sj.ejcn.1602218
  4. Hwang HS, Kim HA, Lee SH, Yun JW. 2008. Anti-obesity and antidiabetic effects of deep sea water on ob/ob mice. Mar Biotechnol (NY) 11:531-539
  5. Jung SJ, Joo EJ, Yoo JY, Kim YK, Cho YJ, Yoon BS, Cho JK, Nam KT, Hwang SG. 2006. Effect of supply of natural water from deep sea rock on the immune response and antioxidant activity in rats. Anim Sci & Technol 48:211-218 https://doi.org/10.5187/JAST.2006.48.2.211
  6. Kim WJ, Li H, Yoon TJ, Sim JM, Choi SK, Lee KH. 2009. Inhibitory activity of brine mineral water on cancer cell growth, metastasis and angiogenesis. Korean J Food & Nutr 22:542-547
  7. Kim YJ, Jung IS, Song HJ, Choi EY, Choi IS, Choi YJ. 2008. Study of deep ground sea-like water on antioxidant activity and the immune response in RAW264.7 macrophages. J Life Sci 18:329-335 https://doi.org/10.5352/JLS.2008.18.3.329
  8. Kimata H, Tai H, Nakagawa K, Yokoyama Y, Nakajima H, Ikegami Y. 2002. Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS). Acta Med 45:83-84
  9. Moon DS, Jung HJ, Kim HJ, Shin PK. 2004. Comparative analysis on resources characteristics of deep ocean water and brine groundwater. J Korean Soc for Marine Environ Engi 7:185-189
  10. Schneider C, Dose W, Zollner TM, Rose L. 2009. Chronic mouse model of YMA-induced contact hypersensitivity. J Invest Dermatol 129:899-907 https://doi.org/10.1038/jid.2008.307
  11. Shon YH, Kim MK, Nam KS. 2008. Effect of deep sea water on cytochrom P450 1A1, aromatase and MMP-9. J Life Sci 18:503-508 https://doi.org/10.5352/JLS.2008.18.4.503