Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Percutaneous absorption Characteristics of Anti hyperlipidemia Gel Ointment using Fibric acid

Fibric acid를 이용한 항고지혈증 겔 연고의 경피 흡수 특성

  • Jung, Duck-Chae (Department of Chemistry, University of Incheon) ;
  • Hwang, Sung-Kwy (Department of Fine Chemistry, Seoul National University of Science and Technology) ;
  • Oh, Se-Young (Department of Fine Chemistry, Seoul National University of Science and Technology)
  • 정덕채 (인천대학교 자연과학대학 화학과) ;
  • 황성규 (서울과학기술대학교 정밀화학과) ;
  • 오세영 (서울과학기술대학교 정밀화학과)
  • Received : 2010.09.10
  • Accepted : 2010.12.15
  • Published : 2010.12.31
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Abstract

New biological treatments were being developed at a record place, but their potential could be compromised by a significant obstacle: the delivery of these drugs into a body. Pharmaceutical delivery is now nearly as important as product. New systems are being developed, and Drug Delivery Markets Series cover these new systems. Transdermal Delivery System(TDS) is often used as a method of drug dosage into the epidermic skin. An approach used to delivery drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other methods of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stopped if the drug dosage lead to side effect. Polysaccharides, such as karaya gum and glucomannan, were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, drug contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in fibric acid(ciprofibrate) such as lipophilic drug in vitro. We used glycerin, PEG400 and PEG800 as enhancers. Since dermis has more water content(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when PEG400 was more effective for lipophilic drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. Especially, this result suggests a possible use of polysaccharide gel ointment matrix as a transdermal delivery system of anti-hyperlipoproteinemic agent.

Keywords

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