Warfarin 복용시 인삼(人蔘)이 포함된 한약처방이 PT INR에 미치는 영향 - 10 증례보고 -

Influence of Herbal Medicines which include Ginseng Co-administration on the PT INR in Patients Taking Warfarin : 10 Case Series

  • 권승원 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 박주영 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 변형식 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 윤승규 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 서유리 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 정우상 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 문상관 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 조기호 (경희의료원 한방병원 한방2내과(심계내과학교실)) ;
  • 김영석 (경희의료원 한방병원 한방2내과(심계내과학교실))
  • Kwon, Seung-Won (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Joo-Young (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Byeon, Hyung-Sik (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Yoon, Seung-Kyu (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Seo, Yu-Ri (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Ki-Ho (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Young-Suk (Dept. of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
  • 발행 : 2010.09.30

초록

Objective : Interaction of warfarin with herbal medicines still remains controversial. The aim of this study was to examine the effect of herbal medicines which contain ginseng on PT INR in patients being treated with warfarin. Method : We studied patients who take herbal medicines which contain ginseng with warfarin during their hospitalization. We retrospectively investigated the effect of herbal medicines which contain ginseng. 10 patients were assigned to receive one of the following adjuncts: Group A (n=4) that received Bojungikkitang-gagam, Group B (n=2) that received Ukgunjatang-gagam, and Group C (n=4) that received Shihogyeji-tang, Gamiondam-tang, Gwininaanshim-tang, and Saengpe-san together. We then investigated changes of PT INR in each group. Result : In group A, there were diminutions of PT INR in 3 cases, and increment in 1 case. In group B, there were increments of PT INR in both cases. In group C, there were increments of PT INR in 3 cases and there was no big change in 1 case. Conclusion : In this study, we found that the interaction of combined herbal medicine is very complicated. So, we must study further more study about interactions of combined herbal medicine on PT INR.

키워드

참고문헌

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