Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Characteristics of Difficult to Treat Asthma in Korea

국내 난치성 천식의 특징 - 파일럿 연구

  • Yoo, Kwang-Ha (Department of Internal Medicine, Konkuk University College of Medicine) ;
  • Lee, Kwan-Ho (Department of Internal Medicine, Yeungnam University College of Medicine) ;
  • Uh, Soo-Taek (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Park, Yong-Bum (Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Rhee, Yang-Keun (Department of Internal Medicine, Chonbuk National University College of Medicine) ;
  • Oh, Yeon-Mok (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • 유광하 (건국대학교 의과대학 내과학교실) ;
  • 이관호 (영남대학교 의과대학 내과학교실) ;
  • 어수택 (순천향대학교 의과대학 내과학교실) ;
  • 박용범 (한림대학교 의과대학 강동성심병원 내과학교실) ;
  • 이양근 (전북대학교 의과대학 내과학교실) ;
  • 오연목 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 천식연구회
  • Received : 2010.08.19
  • Accepted : 2010.09.27
  • Published : 2010.11.30
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Abstract

Background: Difficult-to-treat asthma afflicts a small percentage of the asthma population. However, these patients remain refractory to treat, and account for 40% to 50% of the health costs of asthma treatment, incurring significant morbidity. We conducted a multi-center cross-sectional study to characterize difficult-to-treat asthma in Korea. Methods: Subjects with difficult-to-treat asthma and subjects with controlled asthma were recruited from 5 outpatient clinics of referral hospitals. We reviewed medical records of previous 6 months and obtained patient-reported questionnaires composed of treatment compliance, asthma control, and instruments for stress, anxiety, and depression. Results: We recruited 21 subjects with difficult-to-treat asthma and 110 subjects with controlled asthma into the study. The subjects with difficult-to-treat asthma were associated with longer treatment periods, more increased health care utilization, more medication (oral corticosteroids, number of medication), and more anxiety disorder compared to those of well-controlled asthmatics. There was no difference in age, gender, history of allergy, serum IgE, blood eosinophil count, or body mass index between the 2 groups. Conclusion: Difficult-to-treat asthma is characterized by increased health care utilization and more co-morbidity of anxiety.

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