Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Synthesis, Molecular and Microstructural Study of Poly-N-Vinylpyrrolidone Oximo-L-Valyl-Siliconate with IR, 1H-NMR and SEM

  • Singh, Man (Chemistry Research Lab, Deshbandhu College, University of Delhi) ;
  • Padmaja, G. Vani (Chemistry Research Lab, Deshbandhu College, University of Delhi)
  • Received : 2010.02.02
  • Accepted : 2010.04.04
  • Published : 2010.07.20
Download PDF
⟨ Previous Next ⟩

Abstract

By reducing PVP with $H_2NOH$.HCl and NaOH 2:2:1 mass ratios in aqueous ethanol, poly-N-vinyl pyrrolidone oxime [PVPO] was prepared with 92% yield. Applying the sol-gel concept, orthosilicic acid [OSA] was made by hydrolyzing TEOS with ethanol in 1:0.5 molar ratios using 1 N KOH aqueous solution as a catalyst. The OSA + PVPO + $_L$-Valine ($\alpha$-amino acid) were mixed with pure ethanolic medium in 1:2:2 mass ratios and refluxed at $78^{\circ}C$ and 6 pH for 6.5 h. A white residue of poly-N-vinyl pyrrolidone oximo-L-valyl-siliconate [POVS] appeared after 5 h. The heating of reaction mixture was stopped and the contents were brought to NTP. The residue formation of POVS was intensified with lowering a temperature and completely solidified within 5 h, was filtered using a vacuum pump with Whatmann filter paper no. 42. The residue of POVS was washed several times with 20% aqueous cold ethanolic solution and dried in vacuum chamber at $25^{\circ}C$ for 24 h. The MP was noted above $350^{\circ}C$. Structural and internal morphology were analyzed with IR and $^1H$-NMR, and SEM respectively. A drug loading and transporting ability of the POVS in water and at pH = 5 and 8 was determined chromatographically.

Keywords

References

  1. Tan, X.; Li, M.; Cai, P.; Luo; L.; Zou, X. Anal. Biochem. 2005, 337, 111. https://doi.org/10.1016/j.ab.2004.10.040
  2. Smirnova, I.; Suttiruengwong, S.; Seiler, M.; Arlt, W. Pharmaceutical Development and Technology 2005, 9, 4443.
  3. Watanabe, T.; Hasegawa, S.; Wakiyama, N.; Kusai, A.; Senna, M. Intern. J. Pharma. 2003, 250, 283. https://doi.org/10.1016/S0378-5173(02)00549-5
  4. Castro, R. P.; Cohen, Y.; Monbouquette, H. G. J. Memb. Sci. 1996, 115, 179. https://doi.org/10.1016/0376-7388(96)00019-1
  5. Kei, T.; Hiromitsu, K. J. Sol-Gel Sci. Techn. 2004, 32, 1.
  6. Hakan, P.; Torvard, C. L.; Torgny, L.; Lennart, K. Anal. Biochem. 1978, 88, 271. https://doi.org/10.1016/0003-2697(78)90419-0
  7. Stephen, D. B. J. Biomed. Mater. Res. 2004, 7(5), 387.
  8. Man, S.; Sushila, C. J. Appl. Polym. Sci. 2007, 104, 3261. https://doi.org/10.1002/app.25681
  9. Man, S.; Vinod, K. J. Appl. Polym. Sci. 2009, 114, 1870. https://doi.org/10.1002/app.30805
  10. Man, S.; Dolly, Y.; Rajesh K, Y. J. Appl. Polym. Sci. 2009, 110, 2601.
  11. Singapore, Pat. No. 126089.
  12. Feng, W.; He, H.; Timothy, J. B.; Christian, B.; Clive, A. P. Mol. Pharm. 2009.
  13. Timoshenko, V. Y.; Kudryavtsev, A. A.; Osminkina, L. A.; Vorontsov, A. S.; Ryabchikov, Y. V.; Belogorokhov, I. A.; Kovalev, D.; Kashkarov, P. K. JETP Letters 2006, 83, 9.
  14. Sergey, M. B.; Ingo, K. Analyst 2008, 133, 1302. https://doi.org/10.1039/b805432k