The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Vasorelaxant Effect of Gangwhal in Korean and Chinese on Rat Thoracic Aorta Rings

강활류(羌活類) 한약재(韓藥材)의 혈관이완(血管弛緩) 효과(效果) 비교(比較) 연구(硏究)

  • Lee, Kyung-Jin (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Deok-Soo (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Ham, In-Hye (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ho-Kyoung (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Bu, Young-Min (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Ho-Cheol (Department of Herbology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Ho-Young (Department of Herbology, College of Oriental Medicine, Kyung Hee University)
  • 이경진 (경희대학교 한의과대학 본초학교실) ;
  • 김덕수 (경희대학교 한의과대학 본초학교실) ;
  • 함인혜 (경희대학교 한의과대학 본초학교실) ;
  • 김호경 (한국한의학 연구원 한약자원연구센터) ;
  • 부영민 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실) ;
  • 최호영 (경희대학교 한의과대학 본초학교실)
  • Received : 2010.11.07
  • Accepted : 2010.12.15
  • Published : 2010.12.30
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Abstract

Objectives : The root and rhizome of "Gangwhal" have been used as a traditional medicine for the treatment of cold, fever, headache, swelling, arthritis, rhinitis, and cardiovascular diseases in Korea and china. In china, Gangwhal is well known as a useful oriental medicinal plant that treats cardiovascular diseases such as stroke, headache and hypertension, but little research exists about the effect of O. koreanum on cardiovascular disease. Therefore we investigated the vasorelaxant effects of O. koreanum and compared the vasorelaxant effects of four species of Gangwhal. Methods : The vasorelaxant effects of the ethanol extracts of Ostericum koreanum (NK and BK), Notopterygium incisium (NI), and N. forbesii (NF) on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. The vasorelaxant effects of the water extract and ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. And the vasorelaxant effects of chloroform, ethylacetate and water fraction of ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. Results : Ethanol extracts of NK, BK, NI and NF relaxed rat thoracic aorta rings with a concentration-dependent manner, and NK showed the greatest vasorelaxant effect. And ethanol extract of NK was much more effective than water extract of NK. Finally, chloroform, ethylacetate and water fraction of ethanol extract of NK also relaxed rat thoracic aorta rings, and chloroform fraction showed the greatest vasorelaxant effect.

Keywords

References

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