Korean Journal of Occupational Health Nursing (한국직업건강간호학회지)

Korean Academic Society of Occupational Health Nursing (한국직업건강간호학회)
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Influence of Epinephrine and Norepinephrine on the Risk of Metabolic Syndrome Occurrence in Workers Exposed to Hazardous Chemicals

유해화학물질 노출 근로자의 대사증후군 발생위험에 대한 epinephrine과 norepinephrine의 영향

  • Heo, Kyung-Hwa (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim, Ki-Woong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 허경화 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김기웅 (한국산업안전보건공단 산업안전보건연구원)
  • Received : 2010.04.06
  • Accepted : 2010.05.25
  • Published : 2010.05.31
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Abstract

Purpose: The aim of the present study was to clarify effects of long term, low-level monocyclic aromatic hydrocarbons exposure (MAHs) such as styrene, toluene and xylene on physiological levels of epinephrine (EP) and norepinephrine (NEP) and these hormones influences diagnosis indices of metabolic syndrome (MetS). Methods: Blood pressure and serum biochemical parameters were measured using digital sphygmomanometer and autochemical analyzer. EP and NEP were analyzed by using ELISA kit and exposure level of MAHs was measured by NIOSH method. Results: The differences of general characteristics such as age, smoking and drinking habits in both groups were not significantly different except working hours per day. In exposed workers, exposure levels of MAHs showed very low concentrations. Serum HDL-cholesterol concentration was significantly higher in exposed group, but concentration of NEP was significantly higher in control group. On multiple logistic regression analysis for the diagnosis indices of MetS, EP was WC (OR=0.970), NEP was blood pressure (OR=1.002) and MAHs exposure were significantly associated with HDL-cholesterol (OR=0.257), fasting glucose (OR=3.028) and MetS (OR=0.372). Conclusion: These findings suggest that the chronic exposure of low level MAHs maycontribute to glucose metabolism and induction of MetS. And also, changes of EP and NEP levels by exposure of MAHs affect blood pressure.

Keywords

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