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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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An evolving integrative physiology: skeleton and energy metabolism

  • Lee, Na-Kyung (Department of Biomedical Laboratory Science, College of Medical Science, Soonchunhyang University)
  • Received : 2010.07.14
  • Published : 2010.09.30
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Abstract

The adipocyte-derived hormone leptin regulates appetite and bone mass. Recent research demonstrates that reciprocally, osteoblasts have a role in controlling energy metabolism. Several genes expressed in osteoblasts are involved in this process, and one of them is the Esp gene. The remaining genes regulate Esp gene expression. OST-PTP, the protein name of Esp, regulates the carboxylation of osteocalcin secreted from osteoblasts, thus affecting insulin sensitivity and insulin secretion. This review provides evidence for a novel interpretation of the connection between bone and energy metabolism and expands our understanding of the novel physiology of bone beyond its classical functions.

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References

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