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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Propamidine decreas mitochondrial complex III activity of Botrytis cinerea

  • Wu, Fangli (Center of Biopesticide Engineering and Technology, Northwest A & F University) ;
  • Jin, Weibo (The College of Life Sciences, Northwest A&F University) ;
  • Feng, Juntao (Center of Biopesticide Engineering and Technology, Northwest A & F University) ;
  • Chen, Anliang (Center of Biopesticide Engineering and Technology, Northwest A & F University) ;
  • Ma, Zhiqing (Center of Biopesticide Engineering and Technology, Northwest A & F University) ;
  • Zhang, Xing (Center of Biopesticide Engineering and Technology, Northwest A & F University)
  • Received : 2010.02.01
  • Accepted : 2010.07.24
  • Published : 2010.09.30
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Abstract

Propamidine, an aromatic diamidine compound, is widely used as an antimicrobial agent. To uncover its mechanism on pathogenetic fungi, Botrytis cinerea as an object was used to investigate effects of propamidine in this paper. The transmission electron microscope results showed that the mitochondrial membranes were collapsed after propamidine treatment, followed that mitochondria were disrupted. Inhibition of whole-cell and mitochondrial respiration by propamidine suggested that Propamidine is most likely an inhibitor of electron transport within Botrytis cinerea mitochondria. Furthermore, the mitochondrial complex III activity were inhibited by propamidine.

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References

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