The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Acori Rhizoma Extract on the in vitro Anti-platelet Activity in Human Whole Blood

창포류 추출물이 인간 전혈혈소판 응집억제에 미치는 영향

  • Choi, Go-Ya (Creative Research Team, Korea Institute of Oriental Medicine) ;
  • Kim, Seul-Ki (Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine) ;
  • Lee, In-Sun (Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine) ;
  • Baek, Ji-Seong (Department of Herbology, College of Oriental Medicine, Woosuk University) ;
  • Jeon, Won-Kyung (Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine)
  • 최고야 (한국한의학연구원 창의연구실) ;
  • 김슬기 (한국한의학연구원 신한방제제연구센터) ;
  • 이인선 (한국한의학연구원 신한방제제연구센터) ;
  • 백지성 (우석대학교 한의과대학 본초방제학교실) ;
  • 전원경 (한국한의학연구원 신한방제제연구센터)
  • Received : 2010.08.10
  • Accepted : 2010.09.13
  • Published : 2010.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : Acori Rhizoma is one of the common widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-platelet activity of Acori Rhizoma. The present study examined the effects on platelet aggregation by Acori Rhizoma. Methods : In this study, we tested the in vitro effect of 16 kinds of Acori Rhizoma extracts by hot water or 70% ethanol on collagen-induced platelet aggregation in human whole blood using the impedance method of aggregometry. Results : Among them, 2 kinds of 70% ethanol extract and 1 kind of hot water extract showed the significant inhibiting effect on whole blood aggregation. In particular, Acorus gramineus extracts were selected as the most effective candidate. Conclusiions : The results from this experiment provide pharmacological evidence for the traditional medicine, suggesting that Acorus gramineus could be help problems of blood circulation more than Acorus tatarinowii.

Keywords

References

  1. 이재홍. 혈관성 치매의 치료. J Korean Neurol Assoc. 2003;21(5):445-54.
  2. 전국한의과대학 공동교재편찬위원회. 본초학. 서울:도서출판 영림사. 2004:565-6.
  3. 주영승. 운곡본초학(下). 서울:도서출판 서림재. 2004:304-6.
  4. 식품의약품안전청. 대한약전외한약(생약)규격집. 2007:209.
  5. 国家药典委员会. 中华人民共和国药典. 北京:化学工业出版社. 2005:62.
  6. 國家藥典委員會. 中華人民共和國藥典. 北京:中國醫藥科技出版社. 2010:85.
  7. 최고야. 한약기원정리집. 파주:한국학술정보. 2008:40.
  8. 徐有光, 張全文, 高蘭一. 菖蒲有多種, 用時須辨淸. 中國醫藥指南. 2008;6(22):170-1.
  9. 최고야. 석창포의 내외부형태와 이화학적패턴 연구. 우석대학교 대학원 석사학위논문. 2007.
  10. 張立國. 3種菖蒲類藥材的鑑別與應用. 現代中西醫結合雜誌. 2008;17(11):1705-6.
  11. 陳大霞, 陳俊華. 菖蒲類藥材的鑑定硏究. 重慶中草藥硏究. 2007;1:5-7.
  12. 翁靑荷. 石菖蒲與易混品水菖蒲的鑑別. 海峽藥學. 2006; 18(1):107-8.
  13. Liao JF, Huang SY, Jan TM, Yu LL, Chen CF. Central inhibitory effects of water extract of Acori graminei rhizoma in mice. Journal of Ethnopharmacology. 1998;61(3):185-93. https://doi.org/10.1016/S0378-8741(98)00042-7
  14. Oh MH, Houghton PJ, Whang WK, Cho JH. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine. 2004;11(6):544-8. https://doi.org/10.1016/j.phymed.2004.03.001
  15. Cho JS, Kim YH, Kong JY, Yang CH, Park CG. Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus . Life Sci. 2002;71(5):591-9. https://doi.org/10.1016/S0024-3205(02)01729-0
  16. Mukherjee PK, Kumar V, Mal M, Houghton PJ. Acetylcholinesterase inhibitors from plants. Phytomedicine. 2007;14(4):289-300. https://doi.org/10.1016/j.phymed.2007.02.002
  17. Armida PT, Quan SD, Jose Y, Sylvie AY, Adam KM. Inhibition of platelet aggregation in whole blood by alcohol. Thrombosis Research. 1995;78(2):107-15. https://doi.org/10.1016/0049-3848(95)00039-9
  18. 전원경, 김정희, 이아영, 김호경. 한약재의 전혈혈소판응집억제. 한국한의학연구원논문집. 2003;9(2):55-67.
  19. 전원경, 김호경, 이주현, 고병섭, 이아영, 이경구, 신현규. KIOM2003-080 처방에 대한 항혈전 효능 연구. Korean Journal of Oriental Medicine. 2007;13(2): 143-7.
  20. Jeon WK, Kim YE, Park SO, Kwon DY, Ahn SW, Lee JH, Ji MS, Ko BS. The modified Je-Ho-Tang, Korean herbal medicine, inhibits whole-blood aggregation and platelet adhesion to collagen under flow. Thromb Res. 2008;122(6); 804-9. https://doi.org/10.1016/j.thromres.2008.03.002
  21. Jeon WK, Lee JH, Kim HK, Lee AY, Lee SO, Kim YS, Ryu SY, Kim SY, Lee YJ, Ko BS. Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. J Ethnopharmacol. 2006;106(1);62-9. https://doi.org/10.1016/j.jep.2005.12.015
  22. 신경섭, 이정진, 김영일, 유지연, 박은석, 임지현, 유순향, 오기완, 이명구, 위재준, 김영숙, 윤여표. 건강한 지원자에서 홍삼농축액의 혈행개선 효과: 무작위, 이중맹검, 위약-대조 시험. 고려인삼학회. 2007;31(2):109-16.
  23. 전원경, 유보경, 김영은, 박선옥, 박선민, 고병섭. 한약재 추출물에 대한 전혈 응집억제 효능 검색. J Korean Soc Appl Biol Chem. 2007;50(4):352-7.
  24. Harlan JM, Harker LA. Hemostasis, thrombosis, and thromboembolic disorders; The role of arachidonic acid metabolites in platelet-vessel wall interactions. Med Clin North Am. 1981;65(4):855-80. https://doi.org/10.1016/S0025-7125(16)31502-4
  25. 박호철. Pharmacologic treatment for peripheral arterial disease:antithrombotic drugs. 대한혈관외과학회지. 2003;19(2):227-9.
  26. Jeon WK, Yoo BK, Ahn SY, Lee JH, Ahn SW, Ko BS. A trend of Yin-tonifying formulas compared with Yang-tonifying formulars on anti-platelet and anti-thrombotic activity. The Jornal of Korean Oriental Medicine. 2009;30(6):8-15.
  27. 한국한의학연구원. 한의고전명저총서(http://jisik.kiom.re.kr).