Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Investigation of bone formation using calcium phosphate glass cement in beagle dogs

  • Lee, Seung-Bum (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Jung, Ui-Won (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Choi, Youn-A (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Jamiyandorj, Otgonbold (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Kim, Chang-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Lee, Yong-Keun (Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry) ;
  • Chai, Jung-Kiu (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry)
  • Received : 2010.04.06
  • Accepted : 2010.05.19
  • Published : 2010.06.30
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Abstract

Purpose: Among available biomaterials, bioceramics have drawn special interest due to their bioactivity and the possibility of tailoring their composition. The degradation rate and formulation of bioceramics can be altered to mimic the compositions of the mineral phase of bone. The aim of this study was to investigate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) synthesized by a melting and quenching process. Methods: In five male beagle dogs, $4{\times}4$ mm 1-wall intrabony defects were created bilaterally at the mesial or distal aspect of the mandibular second and fourth premolars. Each of the four defects was divided according to graft materials: CPGC with collagen membrane (CM), biphasic calcium phosphate (BCP) with CM, CM alone, or a surgical flap operation only. The dogs were sacrificed 8 weeks post-surgery, and block sections of the defects were collected for histologic and histometric analysis. Results: There were significant differences in bone formation and cementum regeneration between the experimental and control groups. In particular, the CPGC and BCP groups showed greater bone formation than the CM and control groups. Conclusions: In conclusion, CPGC was replaced rapidly with an abundant volume of new bone; CPGC also contributed slightly to regeneration of the periodontal apparatus.

Keywords

References

  1. Parikh SN. Bone graft substitutes in modern orthopedics. Orthopedics 2002;25:1301-9.
  2. Ahlmann E, Patzakis M, Roidis N, Shepherd L, Holtom P. Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes. J Bone Joint Surg Am 2002;84A:716-20.
  3. Kurashina K, Kurita H, Wu Q, Ohtsuka A, Kobayashi H. Ectopic osteogenesis with biphasic ceramics of hydroxyapa-tite and tricalcium phosphate in rabbits. Biomaterials 2002;23:407-12. https://doi.org/10.1016/S0142-9612(01)00119-3
  4. Jarcho M, Kay JF, Gumaer KI, Doremus RH, Drobeck HP. Tissue, cellular and subcellular events at a bone-ceramic hydroxylapatite interface. J Bioeng 1977;1:79-92.
  5. Rabalais ML, Jr., Yukna RA, Mayer ET. Evaluation of durapatite ceramic as an alloplastic implant in periodontal osseous defects. I. Initial six-month results. J Periodontol 1981;52:680-9. https://doi.org/10.1902/jop.1981.52.11.680
  6. Gao H, Tan T, Wang D. Effect of composition on the release kinetics of phosphate controlled release glasses in aqueous medium. J Control Release 2004;96:21-8. https://doi.org/10.1016/j.jconrel.2003.12.030
  7. Bagambisa FB, Joos U, Schilli W. Interaction of osteogenic cells with hydroxylapatite implant materials in vitro and in vivo. Int J Oral Maxillofac Implants 1990;5:217-26.
  8. Kim YK, Yun PY, Lim SC, Kim SG, Lee HJ, Ong JL. Clinical evaluations of OSTEON as a new alloplastic material in sinus bone grafting and its effect on bone healing. J Biomed Mater Res B Appl Biomater 2008;86:270-7.
  9. Hosono H, Abe Y. Porous glass-ceramics composed of a titanium phosphate crystal skeleton: a review. J Non-Cryst Solids 1995;190:185-97. https://doi.org/10.1016/0022-3093(95)00309-6
  10. Lee BH, Kim MC, Kim KN, LeGeros RZ, Lee YK. Biodegradable bone cement using calcium phosphate glass. Key Eng Mater 2006;309-311:861-4. https://doi.org/10.4028/www.scientific.net/KEM.309-311.861
  11. Nery EB, Eslami A, Van Swol RL. Biphasic calcium phosphate ceramic combined with fibrillar collagen with and without citric acid conditioning in the treatment of periodontal osseous defects. J Periodontol 1990;61:166-72. https://doi.org/10.1902/jop.1990.61.3.166
  12. Bohner M. Physical and chemical aspects of calcium phosphates used in spinal surgery. Eur Spine J 2001;10 Suppl 2:S114-21. https://doi.org/10.1007/s005860100276
  13. Bunker BC, Arnold GW, Wilder JA. Phosphate glass dissolution in aqueous solutions J Non-Cryst Solids 1984;64:291-316. https://doi.org/10.1016/0022-3093(84)90184-4
  14. Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol 2003;8:266-302. https://doi.org/10.1902/annals.2003.8.1.266
  15. Dias AG, Lopes MA, Gibson JR, Santos JD. In vitro degradation studies of calcium phosphate glass ceramics prepared by controlled crystallization. J Non-Cryst Solids 2003;330:81-9. https://doi.org/10.1016/j.jnoncrysol.2003.08.056
  16. Maus U, Andereya S, Gravius S, Ohnsorge JA, Niedhart C, Siebert CH. BMP-2 incorporated in a tricalcium phosphate bone substitute enhances bone remodeling in sheep. J Biomater Appl 2008;22:559-76. https://doi.org/10.1177/0885328207083311
  17. Wolff KD, Swaid S, Nolte D, Bockmann RA, Holzle F, Muller-Mai C. Degradable injectable bone cement in maxillofacial surgery: indications and clinical experience in 27 patients. J Craniomaxillofac Surg 2004;32:71-9. https://doi.org/10.1016/j.jcms.2003.12.002

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