Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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BONE REGENERATION WITH INJECTABLE MPEG-PCL DIBLOCK COPOLYMER AND BONE MARROW MESENCHYMAL STEM CELL

골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생

  • Jeong, You-Min (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Lee, Tai-Hyung (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Park, Jeong-Kyun (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Kim, Won-Suk (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Shin, Joo-Hee (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Lee, Eui-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Rim, Jae-Suk (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Jang, Hyon-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University)
  • 정유민 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이태형 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 박정균 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 김원석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 신주희 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이의석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 임재석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 장현석 (고려대학교 의과대학 구강악안면외과학교실)
  • Received : 2009.11.12
  • Accepted : 2010.01.12
  • Published : 2010.01.29
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Abstract

Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model. Materials and Methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis. Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer. Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.

Keywords

References

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