Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

EFFECT OF SHORT ADMINISTRATION BISPHOSPHONATE TO PERIOSTEUM AND SINUS MEMBRANE AFTER ILIAC BONE GRAFT INTO MAXILLARY SINUS IN RABBIT

Bisphosphonate를 단기간 투여했을 때 초기 골막 및 상악동 점막치유에 미치는 영향

  • Lim, Kwang-Soo (Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University) ;
  • Seo, Go-Eun (Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University) ;
  • Song, Jun-Ho (Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University) ;
  • Lee, Soo-Woon (Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University) ;
  • Park, Sang-Jun (Department of Oral and Maxillofacial Surgery, Pusan Paik hospital, Inje University)
  • 임광수 (인제대학교 의과대학 부산백병원 구강악안면외과) ;
  • 서고은 (인제대학교 의과대학 부산백병원 구강악안면외과) ;
  • 송준호 (인제대학교 의과대학 부산백병원 구강악안면외과) ;
  • 이수운 (인제대학교 의과대학 부산백병원 구강악안면외과) ;
  • 박상준 (인제대학교 의과대학 부산백병원 구강악안면외과)
  • Received : 2009.10.27
  • Accepted : 2010.01.13
  • Published : 2010.01.29
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Abstract

Objective: Bisphosphonate related osteonecrosis of the jaw (BRONJ) is reported in patients taken bisphosphonate for a long time, however, the mechanism of osteonecrosis in BRONJ was not clarified yet. This study was designed to investigate the effect of short administraion zoledronate on the healing pattern of periosteum and sinus membrane after iliac bone graft into maxillary sinus. Methods: In this study, 18 Newzeland rabbits were used. The animals were divided into 2 group. In the experimental group, rabbits were treated with weekly peritoneal injection (0.06 mg/kg/week) of zoledronate for three times. In the control group, rabbits were treated with saline solution injection instead of zoledronate. Periosteum and sinus membrane were harvested from one rabbit of the experimental group and one of the control group in the fourth week. The autogeneous bone was harvested from ilium and grafted into maxillary sinus. The rabbits were sacrificed at 1, 2, 4 and 8 weeks after bone graft. The healing pattern of periosteum and sinus membrane were evaluated histologically. Results: Inflammatory reaction in the periosteum was less conspicuous and healing process appeared earlier in experimental group compared with control group at 1, 2, 4 weeks. There were no differences of microscopic findings of sinus membrane between both groups at any weeks. Conclusion: Short-term use of zoledronate decreased the inflammatory reaction and enhanced healing process in the periosteum. These findings suggest the possibility that zoledronte suppress the function of macrophages.

Keywords

References

  1. Van Poznak CH,: The use of bisphosphonates in patients with breast cancer. Cancer control 9: 480, 2002. https://doi.org/10.1177/107327480200900605
  2. Costa L, Lipton A, Coleman RE: .Role of bisphosphonates for the management of skeletal complications and bone pain from skeletal metastases. Support Cancer Ther. 3 : 143, 2006. https://doi.org/10.3816/SCT.2006.n.012
  3. Rosen LS, Gordon D. Kaminski M et al,: Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer of osteolytic lesions of multiple myeloma: A phase III. double-blind,comparative trial. Cancer J 7: 377, 2001.
  4. Marx RE,Fortin M,Broumand V,: Bisphosphonate-induced exposed bone (osteonerosis/osteopetrosis) of the jaws: Risk factors,recognition,prevention and treatment. J Oral Maxillofacial Surg 63: 1567, 2005. https://doi.org/10.1016/j.joms.2005.07.010
  5. American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-related Osteonecrosis of the Jaws. J Oral Maxillofac Surg 65: 369, 2007. https://doi.org/10.1016/j.joms.2006.11.003
  6. Hoff AO, Toth BB, Altundag V et al,: Osteonecrosis of the jaw in patients receiving intravenous bisphosphonate therapy. 2006 ASCO Annual meeting precedings Part I. J Clin Oncol 24: 8528, 2006.
  7. Murad OM, Arora S, Farag AF et al.:. Bisphosphonates and osteonecrosis of the jaw: a retrospective study. Endocr Pract. 13: 232, 2007. https://doi.org/10.4158/EP.13.3.232
  8. Ruggiero SL, Mehrotra B, Rosenberg TJ et al.: Osteonecrosis of the jaws associated with the use of bisphosphonates ; A review of 63 cases. J Oral Maxillofac Surg 62: 527, 2004 . https://doi.org/10.1016/j.joms.2004.02.004
  9. Wood J, Bonj ean K, Ruetz et al.: Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 302: 1055, 2002. https://doi.org/10.1124/jpet.102.035295
  10. Bezzi M, Hasmim M, Bieler G et al.: Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death; Evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt. J Biol Chem 278: 43603, 2003. https://doi.org/10.1074/jbc.M308114200
  11. Altundal H.Guvener O.: The effect of aledronate on resorption of the alveolar bone following tooth extraction. Int J Oral Maxillofac Surg. 33: 286, 2004. https://doi.org/10.1006/ijom.2002.0472
  12. Landeberg R, Cozin M. Cremers S et al.: Inhibition of Oral Mucosal Cell Wound Healing by Bisphosphonates. J Oral Maxillofac Surg 66: 839, 2008. https://doi.org/10.1016/j.joms.2008.01.026
  13. Pampu AA, Dolanmaz D, Tuz HH et al.: Histomophometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits. J Oral Maxillofac Surg. 66: 905, 2008. https://doi.org/10.1016/j.joms.2007.12.004
  14. Cetinkaya BO, Keles GC, Ayas B et al.: Effects of Risedronate on alveolar bone loss and angiogenesis: A Sterologic study in Rats. J Periodontol 79: 1950, 2008. https://doi.org/10.1902/jop.2008.080041
  15. Konstantinos N, Malizos, Loukia K.: The healing potential of the periosteum Molecular aspects. Int. J. Care Injured 36: S13, 2005.
  16. Goran Augustin, Anko Antabak, Slavko Davila.: The periosteum Part1: Anatomy.histology and molecular biology. Int. J Care Injured 38: 1115, 2007. https://doi.org/10.1016/j.injury.2007.05.017
  17. Tatum H.: Maxillary and sinus implant reconstructions. Dent Clin North Am. 30: 207, 1986 .
  18. Jensen OT, Shulman LB, Block MS. : Report of trhe sinus consensus conference of 1996. Int J Oral Maxillofac Implants. 13: 11, 1998.
  19. Roelofs AJ, Thompson K, Gordon S. : Molecular Mechanism of Action of Bisphosphonates : CurrentStatus. Clin Cancer Res. 15: 6222s, 2006.
  20. Fettetti G, Fabi A, CarliniP et al. : Zoledronic-acid induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients. Oncology. 69: 35, 2005. https://doi.org/10.1159/000087286
  21. Boyne P J, James R A, : Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 38: 613, 1980.
  22. Menezes AM, Rocha FA, Chaves HV. : Effect of sodium aledronate on alveolar bone resorption in experimental periodontitis in rats. J Periodontol 76: 1901, 2005. https://doi.org/10.1902/jop.2005.76.11.1901
  23. Mitsuta T, Horiuchi H. Shinoda H. : Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. J Periodontol 73: 479, 2002. https://doi.org/10.1902/jop.2002.73.5.479