Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Bioactive Phenolic Constituents from the Culms of Phyllostachys bambusoides

  • Kim, Hyun-Jung (Research Center for Resistant Cells, School of Medicine, Chosun University) ;
  • Kang, Min-Ah (Kolmar Korea Co., Ltd.) ;
  • Kim, So-Hyun (Biobank of Chonnam National University Hwasun Hospital) ;
  • Yim, Soon-Ho (Gist Technology Institute, Gwangju Institute of Science and Technology) ;
  • Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
  • Received : 2011.09.17
  • Accepted : 2011.10.30
  • Published : 2011.12.30
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Abstract

In our search for bioactive phenolics from plants, the culms of Phyllostachys bambusoides has been selected for investigation of anti-cariogenic and 1,1-diphenylpicrylhydrazyl (DPPH) radical scavenging agents based on the initial screening results. Fractionation process of n-hexane and $CHCl_3$ extracts afforded four phenolic constituents, ferulic acid (1), vanillin (2), coniferaldehyde (3), and coniferyl alcohol (4) as guided by their DPPH free radical scavenging activities. Additionally, activity-guided fractionation of EtOAc extract with anti-cariogenic activity has resulted in the isolation of coniferaldehyde (3), 2,6-dimethoxy-p-benzoquinone (5), p-methoxycinnamic acid (6), (${\pm}$)-balanophonin (7), and 6-methoxychromanone (8). The structures of 1 - 8 were determined by spectroscopic data interpretation, and also by comparison of their data with the published values. Phenolic compounds 1 - 4 exhibited similar DPPH radical scavenging activities compared with the synthetic antioxidant, butylated hydroxytoluene (BHT), and compounds 3 and 5 - 8 showed significant antibacterial activity against cariogenic oral streptococci, Streptococcus mutans and S. sobrinus.

Keywords

References

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