The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effect of Saengmaeg-san Extract on Xerostomia in Stroke Patients : A Double-Blind Randomized Controlled Study

중풍환자의 구강건조증에 대한 생맥산의 효과 : 무작위배정 이중맹검 연구

  • Lee, Dae-Hyun (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Han, Hyun-Jin (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Kim, Lak-Hyung (Dept. of Neuropsychiatry, College of Korean Medicine, Woo-Suk University) ;
  • Kang, Sei-Young (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University) ;
  • Jang, In-Soo (Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University)
  • 이대현 (우석대학교 한의과대학 한방내과학교실) ;
  • 한현진 (우석대학교 한의과대학 한방내과학교실) ;
  • 김락형 (우석대학교 한의과대학 한방신경정신과학교실) ;
  • 강세영 (우석대학교 한의과대학 한방내과학교실) ;
  • 장인수 (우석대학교 한의과대학 한방내과학교실)
  • Published : 2011.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The present study was made to evaluate the clinical effectiveness of Saengmaeg-san (生脈散) extract to treat xerostomia in stroke patients. Methods : The study design was a double-blind randomized controlled trial. Subjects were stroke patients with xerostomia. They were allocated to either the Saengmaeg-san (n=12) or placebo group (n=12). Saengmaeg-san extract or a placebo in similar opaque capsules was given three times a day for a week. The improvement of xerostomia was measured by the xerostomia-evaluating questionnaire, developed by the school of dentistry in Seoul National University, before baseline and one week later. Eleven of the Saengmaeg-san group and ten of the placebo group finished the trial and were analyzed. Paired samples t-test and Mann-Whitney test were applied to statistical analysis. Results : On three of the six questions, the Saengmaeg-san group improved significantly. On two of the six questions, the Saengmaeg-san group improved significantly more than the placebo group. On the other questions, the Saengmaeg-san group improved more than the placebo group, although significance was not reached. Conclusions : These results demonstrate that Saengmaeg-san extract is effective for treating xerostomia in stroke patients, and further studies should be conducted to provide more valuable information.

Keywords

References

  1. Fox PC. Management of dry mouth. Dent Clin North Am 1997;41(4):863-75.
  2. Billings RJ, Proskin HM, Moss ME. Xerostomia and associated factors in a community dwelling adults population. Community Dent Oral Epidemiol 1996;24:312-6. https://doi.org/10.1111/j.1600-0528.1996.tb00868.x
  3. 채병윤. 동의안이비인후과학. 서울: 집문당; 2011, p. 444, 461-2.
  4. 張介賓. 景岳全書(1624年 初刊). 서울: 한미의학; 2006, p. 1220-1.
  5. Cassolato SF, Turnbull RS. Xerotomia: Clinical aspects and treatment. Gerontology 2003;20:64-77.
  6. Matear DW, Locker D, stephens M, Lawrence HP. Associations between xerostomia and health status indicators in the elderly. J R Soc Promot Health 2006;126:79-85. https://doi.org/10.1177/1466424006063183
  7. Turner MD, Ship JA. Dry mouth and its effects on the oral health of elderly people. J Am Dent Assoc 2007;138:155-205.
  8. 박명숙, 류세앙. 지역사회 노인의 구강건조증 정도 및 구강건강관련 삶의 질 영향요인. 대한간호학회지 2010;40(5):747-55.
  9. Kerr GD, Sellars C, Bowie L, Bagg J, Sweeney MP, Langhorne P, et al. Xerostomia after acute stroke. Cerebrovasc Dis 2009;28(6):624-6. https://doi.org/10.1159/000253147
  10. 신재용. 방약합편해설. 서울: 전통의학연구소; 2005, p. 27-8, 137-8.
  11. 常靑. 實用中風防治手冊. 北京: 中國中醫藥出版社; 1993, p. 22-4.
  12. Field EA, Fear S, Higham SM, Ireland RS, Rostron J, Willetts RM, et al. Age and medication are significant risk factors for xerostomia in an English population, attending general dental practice. Gerontology 2001;18(1):21-4.
  13. Guggenheimer J, Moore PA. Xerotomia: Etiology, recognition and treatment. J Am Dent Assoc 2003;134(1):61-9.
  14. Gonsalves WC, Wrightson AS, Henry RG. Common oral conditions in older persons. Am Fam Physician 2008;78(7):845-52.
  15. Nederfors T. Xerostomia and Hyposalivation. Adv Dent Res 2000;14:48-56. https://doi.org/10.1177/08959374000140010701
  16. Soderling E, Le Bell A, Kirstilä V, Tenovuo J. Betaine-containing toothpaste relieves subjective symptoms of dry mouth. Acta Odontol Scand 1998;56(2):65-9. https://doi.org/10.1080/00016359850136003
  17. 박준봉. 고령자의 구강건강 관리. 대한노년치의학회지 2004;1(1):27-9.
  18. 두호경. 동의내경학. 서울: 교학사; 2004, p. 489.
  19. 許浚. 新對譯東醫寶鑑(1613年 初刊). 서울: 법인문화사; 2007, p. 402, 681, 1242-3.
  20. 윤용갑. 동의방제와 처방해설. 서울: 의성당; 2007, p. 168.
  21. 전국한의과대학 본초학교수 공저. 본초학. 서울: 영림사; 2000, p. 531-3, 588-9, 622-3.
  22. Fox PC, Busch K, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 1987;115:581-4.
  23. Nederfors T. Xerostomia: Prevalence and pharmacotherapy. With special reference to adrenoreceptor antagonists. Swed Dent J 1996;116:1-70.
  24. Thomson WM, Chalmers JM, Spencers AJ, Ketabi M. The occurrence of xerostomia and salivary gland hypofunction in a population-based sample of older South Australians. Spec Care Dent 1999;19:20-3. https://doi.org/10.1111/j.1754-4505.1999.tb01363.x
  25. Pai S, Ghezzi EM, Ship JA. Development of a Visual Analog Scale questionnaire for subjective assessment of salivary dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:311-6. https://doi.org/10.1067/moe.2001.111551
  26. 이정윤, 이영옥, 고홍섭. 구강건조증 증상 평가를 위한 설문지의 신뢰도에 관한 연구. 대한구강내과학회지 2005;30(4):383-9.